{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:06:53Z","timestamp":1789578413094,"version":"build-2803163510"},"reference-count":113,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part B: Reviews"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>Temporomandibular joint osteoarthritis (TMJOA) is a gradual degenerative jaw joint condition. Until recent years, TMJOA is still relatively unrecognized and ineffective to be treated. Appropriate animal models with reliable detection methods can help researchers understand the pathophysiology of TMJOA and find therapeutic options. In this study, we summarized common animal models of TMJOA created by chemical, surgical, mechanical, and genetical approaches. The relevant pathological symptoms and induction mechanisms were outlined. In addition, different pathological indicators, furthermore, emerging therapeutic regimens, such as intra-articular drug delivery and tissue engineering-based approaches to treat TMJOA based on these animal models, were summarized and updated. Understanding the physiology and pathogenesis of the TMJOA, together using various ways to diagnose the TMJOA, were elaborated, including imaging techniques, molecular techniques for detecting inflammatory cytokines, histochemical staining, and histomorphometry measures. A more reliable diagnosis will enable the development of new prevention and more effective treatment strategies and thereby improve the quality of life of TMJOA patients.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Impact statement<\/jats:title>\n                    <jats:p>Temporomandibular joint osteoarthritis (TMJOA) affects 8 to 16 percent of the population worldwide. However, TMJOA is still relatively unrecognized and ineffective to be treated in the clinic. Appropriate animal models with reliable diagnostic methods can help researchers understand the pathophysiology of TMJOA and find therapeutic options. We herein summarized common animal models of TMJOA and various ways to diagnose the TMJOA. More importantly, emerging therapeutic regimens to treat TMJOA based on these animal models were summarized. With the aid of strategies listed, more effective treatment strategies will be developed and thereby improve the life quality of TMJOA patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ten.teb.2022.0065","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T12:45:34Z","timestamp":1661172334000},"page":"62-77","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":57,"title":["Recent Advances in Animal Models, Diagnosis, and Treatment of Temporomandibular Joint Osteoarthritis"],"prefix":"10.1177","volume":"29","author":[{"given":"Dongyun","family":"Wang","sequence":"first","affiliation":[{"name":"Stomatological Center of Peking University Shenzhen Hospital, Guangdong Provincial High-level Clinical Key Specialty, Guangdong Province Engineering Research Center of Oral Disease Diagnosis and Treatment, Shenzhen, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Qi","sequence":"additional","affiliation":[{"name":"Stomatological Center of Peking University Shenzhen Hospital, Guangdong Provincial High-level Clinical Key Specialty, Guangdong Province Engineering Research Center of Oral Disease Diagnosis and Treatment, Shenzhen, China."},{"name":"Peking University Shenzhen Hospital, Clinical College of Anhui Medical University, Shenzhen, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhubing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Dentistry, Health Science Center, Shenzhen University, Shenzhen, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anyun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, Southern University of Science and Technology Hospital, Shenzhen, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxin","family":"Xu","sequence":"additional","affiliation":[{"name":"Stomatological Center of Peking University Shenzhen Hospital, Guangdong Provincial High-level Clinical Key Specialty, Guangdong Province Engineering Research Center of Oral Disease Diagnosis and Treatment, Shenzhen, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Dentistry, Health Science Center, Shenzhen University, Shenzhen, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2455-4510.IntJResOrthop20160708"},{"key":"e_1_3_4_3_2","unstructured":"Research NIOD. 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