{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:02:02Z","timestamp":1777939322007,"version":"3.51.4"},"reference-count":53,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T00:00:00Z","timestamp":1400803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part C: Methods"],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:p>\n                    Despite the development of a myriad of anticancer drugs that appeared promising in preclinical ovarian cancer animal models, they failed to predict efficacy in clinical testing. To improve the accuracy of preclinical testing of efficacy and toxicity, including pharmacokinetic and pharmacodynamic evaluations, a novel animal model was developed and characterized. In this study, murine ID8 (epithelial ovarian cancer [EOC]) cells as injected cell suspensions (ICS) and as intact cultured monolayer cell sheets (CS) were injected or surgically grafted, respectively, into the left ovarian bursa of 6\u20138 week-old, female C57BL\/6 black mice and evaluated at 8 and 12 weeks after engraftment. Tumor volumes at 8 weeks were as follows: 30.712\u00b118.800\u2009mm\n                    <jats:sup>3<\/jats:sup>\n                    versus 55.837\u00b110.711\u2009mm\n                    <jats:sup>3<\/jats:sup>\n                    for ICS and CS, respectively,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.0990 (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =5). At 12 weeks, tumor volumes were 128.129\u00b144.018\u2009mm\n                    <jats:sup>3<\/jats:sup>\n                    versus 283.953\u00b171.676\u2009mm\n                    <jats:sup>3<\/jats:sup>\n                    for ICS and CS, respectively,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.0112 (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =5). The ovarian weights at 8 and 12 weeks were 0.02138\u00b10.01038\u2009g versus 0.04954\u00b10.00667\u2009g for ICS and CS, respectively (8 weeks),\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.00602 (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =5); and 0.10594\u00b10.03043\u2009g versus 0.39264\u00b10.09271\u2009g for ICS and CS, respectively (12 weeks),\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.0008 (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    =5). These results confirm a significant accelerated tumorigenesis in CS-derived tumors compared with ICS-derived tumors when measured by tumor volume\/time and ovarian weight\/time. Furthermore, the CS-derived tumors closely replicated the metastatic spread found in human EOC and histopathological identity with the primary tumor of origin.\n                  <\/jats:p>","DOI":"10.1089\/ten.tec.2014.0040","type":"journal-article","created":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T00:41:50Z","timestamp":1397868110000},"page":"23-34","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["An Immunocompetent, Orthotopic Mouse Model of Epithelial Ovarian Cancer Utilizing Tissue Engineered Tumor Cell Sheets"],"prefix":"10.1177","volume":"21","author":[{"given":"Ayumi","family":"Arauchi","sequence":"first","affiliation":[{"name":"Tokyo Women's Medical University","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieh-Hsiang","family":"Yang","sequence":"additional","affiliation":[{"name":"University of Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungpil","family":"Cho","sequence":"additional","affiliation":[{"name":"University of Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke A.","family":"Jarboe","sequence":"additional","affiliation":[{"name":"Associated Regional University Pathologists (ARUP) University of Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Matthew","family":"Peterson","sequence":"additional","affiliation":[{"name":"University of Utah"},{"name":"Nano Institute of Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You Han","family":"Bae","sequence":"additional","affiliation":[{"name":"Nano Institute of Utah"},{"name":"University of Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruo","family":"Okano","sequence":"additional","affiliation":[{"name":"Tokyo Women's Medical University","place":["Japan"]},{"name":"Nano Institute of Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margit M.","family":"Jan\u00e1t-Amsbury","sequence":"additional","affiliation":[{"name":"University of Utah"},{"name":"Nano Institute of Utah"},{"name":"University of Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,5,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2644"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.1107"},{"key":"e_1_3_3_5_2","first-page":"357","volume-title":"Altchek's Diagnosis and Management of Ovarian Disorders","author":"Gordon P.S.","year":"2013","unstructured":"Gordon P.S., , and Fishman D. Early detection of ovarian cancer. In: Deligdisch Liane, , Kase Nathan G., , Cohen Carmel J., eds. Altchek's Diagnosis and Management of Ovarian Disorders, third Edition. 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