{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:24:28Z","timestamp":1787505868612,"version":"build-2736575974"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part C: Methods"],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:p>\n                    Successful therapy for radiation-induced salivary gland (SG) hypofunction is currently unavailable; however, tissue-specific stem cells are expected to be promising candidates for SG regeneration. Here, we present our method for the establishment of single cell-derived clonal stem cells from mouse SGs and describe their characteristics. Salivary gland-derived clonal stem cells (SGSCs) were isolated and expanded\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    by a modified subfractionation culture method. The properties of SGSCs were examined with respect to their marker expression, gene expression, differentiation potential, and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    immunosuppressive activity relative to bone marrow-derived mesenchymal stem cells (BM-MSCs). SGSCs appeared to largely share the characteristics of BM-MSCs based on their marker expression, whereas they differentially expressed some genes, including\n                    <jats:italic toggle=\"yes\">AQP5, E-Cadherin, Laminin, ZO-1,<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">COL4<\/jats:italic>\n                    . SGSCs showed the ability to differentiate into fat, bone, and cartilage cell types, as well as into \u03b1-amylase-producing and hepatocyte-like cells after appropriate induction. The\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    immunosuppressive activity of SGSCs was found to be more potent than that of BM-MSCs. These results showed that SGSCs possess the properties of MSCs with some differential gene expression and they are salivary-specific stem cells with both epithelial and mesenchymal properties. The biological functions of SGSCs and their relevance to SG epithelial progenitor cells require further investigation.\n                  <\/jats:p>","DOI":"10.1089\/ten.tec.2014.0204","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T07:26:58Z","timestamp":1412234818000},"page":"447-457","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Establishment and Characterization of Mesenchymal Stem Cell-Like Clonal Stem Cells from Mouse Salivary Glands"],"prefix":"10.1177","volume":"21","author":[{"given":"Jae-Yol","family":"Lim","sequence":"first","affiliation":[{"name":"Inha University School of Medicine"},{"name":"Inha University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TacGhee","family":"Yi","sequence":"additional","affiliation":[{"name":"Inha University School of Medicine"},{"name":"Inha University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyi","family":"Lee","sequence":"additional","affiliation":[{"name":"Inha University School of Medicine"},{"name":"Inha University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghee","family":"Kim","sequence":"additional","affiliation":[{"name":"Inha University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-na","family":"Kim","sequence":"additional","affiliation":[{"name":"Inha University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun U.","family":"Song","sequence":"additional","affiliation":[{"name":"Inha University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Inha University School of Medicine"},{"name":"Inha University School of 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