{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:03:17Z","timestamp":1777939397892,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T00:00:00Z","timestamp":1510531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part C: Methods"],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:p>\n                    Periprosthetic osteolysis and subsequent aseptic loosening of total joint replacements are driven by byproducts of wear released from the implant. Wear particles cause macrophage-mediated inflammation that culminates with periprosthetic bone loss. Most current animal models of particle-induced osteolysis are based on the acute inflammatory reaction induced by wear debris, which is distinct from the slowly progressive clinical scenario. To address this limitation, we previously developed a murine model of periprosthetic osteolysis that is based on slow continuous delivery of wear particles into the murine distal femur over a period of 4 weeks. The particle delivery was accomplished by using subcutaneously implanted osmotic pumps and tubing, and a hollow titanium rod press-fit into the distal femur. In this study, we report a modification of our prior model in which particle delivery is extended to 8 weeks to better mimic the progressive development of periprosthetic osteolysis and allow the assessment of interventions in a setting where the chronic particle-induced osteolysis is already present at the initiation of the treatment. Compared to 4-week samples, extending the particle delivery to 8 weeks significantly exacerbated the local bone loss observed with \u03bcCT and the amount of both peri-implant F4\/80\n                    <jats:sup>+<\/jats:sup>\n                    macrophages and tartrate-resistant acid phosphatase-positive osteoclasts detected with immunohistochemical and histochemical staining. Furthermore, systemic recruitment of reporter macrophages to peri-implant tissues observed with bioluminescence imaging continued even at the later stages of particle-induced inflammation. This modified model system could provide new insights into the mechanisms of chronic inflammatory bone loss and be particularly useful in assessing the efficacy of treatments in a setting that resembles the clinical scenario of developing periprosthetic osteolysis more closely than currently existing model systems.\n                  <\/jats:p>","DOI":"10.1089\/ten.tec.2017.0166","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T03:29:26Z","timestamp":1507174166000},"page":"1003-1011","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["<sup\/>\n                    Murine Model of Progressive Orthopedic Wear Particle-Induced Chronic Inflammation and Osteolysis"],"prefix":"10.1177","volume":"23","author":[{"given":"Jukka","family":"Pajarinen","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Nabeshima","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-hua","family":"Lin","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taishi","family":"Sato","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Gibon","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eemeli","family":"J\u00e4msen","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Lu","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthik","family":"Nathan","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Yao","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart B.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine"},{"name":"Stanford University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB01005A"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.04.035"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34599"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/185150"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65266-2"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00134-X"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199711000-00005"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200202000-00011"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10227"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(00)00033-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.136895"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23368"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.05.031"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1645-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21548"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30451"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142736"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35978"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.02.008"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35532"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22977"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20486"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2012.03.042"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22658"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35913"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(03)00093-7"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200008000-00006"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.orthres.2004.11.005"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.92B6.23666"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35759"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20987"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.10.042"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199411000-00010"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.76B1.8300684"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820290118"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1243\/0954411001535219"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00032-7"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10368"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1084"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-018093"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016199109"}],"container-title":["Tissue Engineering Part C: Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ten.tec.2017.0166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ten.tec.2017.0166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ten.tec.2017.0166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:15:03Z","timestamp":1777698903000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ten.tec.2017.0166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,13]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12,1]]}},"alternative-id":["10.1089\/ten.tec.2017.0166"],"URL":"https:\/\/doi.org\/10.1089\/ten.tec.2017.0166","relation":{},"ISSN":["1937-3384","1937-3392"],"issn-type":[{"value":"1937-3384","type":"print"},{"value":"1937-3392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,13]]}}}