{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:05:39Z","timestamp":1777939539271,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Tissue Engineering Part C: Methods"],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:p>\n                    The aim of this study was to test the suitability of calcium phosphate cement mixed with poly(lactic-\n                    <jats:italic toggle=\"yes\">co<\/jats:italic>\n                    -glycolic acid) (CPC-PLGA) microparticles into a ring-shaped polymeric space-maintaining device as bone graft material for lateral bone augmentation. Therefore, the bone chambers were installed on the lateral portion of the anterior region of the mandibular body of mini-pigs. Chambers were filled with either CPC-PLGA or BioOss\n                    <jats:sup>\u00ae<\/jats:sup>\n                    particles for comparison and left for 4 and 12 weeks. Histology and histomorphometry were used to obtain temporal insight in material degradation and bone formation. Results indicated that between 4 and 12 weeks of implantation, a significant degradation of the CPC-PLGA (from 75.1% to 23.1%), as well as BioOss material, occurred (from 40.6% to 14.4%). Degradation of both materials was associated with the presence of macrophage-like and osteoclast-like cells. Furthermore, a significant increase in bone formation occurred between 4 and 12 weeks for the CPC-PLGA (from 0.1% to 7.2%), as well as BioOss material (from 8.3% to 23.3%). Statistical analysis showed that bone formation had progressed significantly better using BioOss compared to CPC-PLGA (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In conclusion, this mini-pig study showed that CPC-PLGA does not stimulate lateral bone augmentation using a bone chamber device. Both treatments failed to achieve \u201cclinically\u201d meaningful alveolar ridge augmentation.\n                  <\/jats:p>","DOI":"10.1089\/ten.tec.2023.0025","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T04:53:10Z","timestamp":1682052790000},"page":"287-297","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lateral Bone Augmentation Using a Three-Dimensional-Printed Polymeric Chamber to Compare Biomaterials"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3213-5060","authenticated-orcid":false,"given":"Bart","family":"van Oirschot","sequence":"first","affiliation":[{"name":"Regenerative Biomaterials, Department of Dentistry, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-1966","authenticated-orcid":false,"given":"Jeroen J.J.P.","family":"van den Beucken","sequence":"additional","affiliation":[{"name":"Regenerative Biomaterials, Department of Dentistry, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonios G.","family":"Mikos","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Rice University, Houston, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3077-8617","authenticated-orcid":false,"given":"John A.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Regenerative Biomaterials, Department of Dentistry, Radboud University Medical Center, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13121"},{"issue":"4","key":"e_1_3_5_3_2","first-page":"CD003607","article-title":"Interventions for replacing missing teeth: horizontal and vertical bone augmentation techniques for dental implant treatment (Review)","author":"Esposito M","year":"2009","unstructured":"Esposito M, , Grusovin MG, , Karatzopoulos G, et al. 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