{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:07:01Z","timestamp":1777939621848,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T00:00:00Z","timestamp":1412553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:p>\n                    Therapeutic hypothermia improves the survival and neurodevelopmental outcome of infants with newborn encephalopathy of a hypoxic-ischemic origin. The NICHD Neonatal Research Network (NRN) Whole Body Cooling trial used the Cincinnati Sub-Zero Blanketrol II to achieve therapeutic hypothermia. The Blanketrol III is now available and provides additional cooling modes that may result in better temperature control. This report is a retrospective comparison of infants undergoing hypothermia using two different cooling modes of the Blanketrol device. Infants from the NRN trial were cooled with the Blanketrol II using the Automatic control mode (B2 cohort) and were compared with infants from two new NRN centers that adopted the NRN protocol and used the Blanketrol III in a gradient mode (B3 cohort). The primary outcome was the percent time the esophageal temperature stayed between 33\u00b0C and 34\u00b0C (target 33.5\u00b0C) during maintenance of hypothermia. Cohorts had similar birth weight, gestational age, and level of encephalopathy at the initiation of therapy. Baseline esophageal temperature differed between groups (36.6\u00b0C\u00b11.0\u00b0C for B2 vs. 33.9\u00b0C\u00b11.2\u00b0C for B3,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.0001) reflecting the practice of passive cooling during transport prior to initiation of active device cooling in the B3 cohort. This difference prevented comparison of temperatures during induction of hypothermia. During maintenance of hypothermia the mean and standard deviation of the percent time between 33\u00b0C and 34\u00b0C was similar for B2 compared to B3 cohorts (94.8%\u00b10.1% vs. 95.8%\u00b10.1%, respectively). Both the automatic and gradient control modes of the Blanketrol devices appear comparable in maintaining esophageal temperature within the target range during maintenance of therapeutic hypothermia.\n                  <\/jats:p>","DOI":"10.1089\/ther.2014.0009","type":"journal-article","created":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T14:18:33Z","timestamp":1412605113000},"page":"193-200","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Temperature Control During Therapeutic Hypothermia for Newborn Encephalopathy Using Different Blanketrol Devices"],"prefix":"10.1177","volume":"4","author":[{"given":"Abbot R.","family":"Laptook","sequence":"first","affiliation":[{"name":"Alpert Medical School of Brown University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Kilbride","sequence":"additional","affiliation":[{"name":"Children's Mercy Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Nationwide Children's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"McDonald","sequence":"additional","affiliation":[{"name":"RTI International"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seetha","family":"Shankaran","sequence":"additional","affiliation":[{"name":"Wayne State University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Truog","sequence":"additional","affiliation":[{"name":"Children's Mercy Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhik","family":"Das","sequence":"additional","affiliation":[{"name":"RTI International"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary D.","family":"Higgins","sequence":"additional","affiliation":[{"name":"NICHD Neonatal Research Network"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Optimizing Cooling Sub-Committee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,10,6]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038504"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1981.01650010042022"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-301855"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-301647"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.683898"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.207886"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2995"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02562.x"},{"key":"e_1_3_3_10_1","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","volume":"1","author":"Jacobs SE","year":"2013","unstructured":"Jacobs SE, , Berg M, , Hunt R, , Tarnow-Mordi WO, , Inder TE, , Davis PG. 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