{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:08:08Z","timestamp":1777939688497,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2019,3,1]]},"abstract":"<jats:p>\n                    Ischemia\u2013reperfusion (I\/R)-induced oxidative stress is one of the main mechanisms of tissue injury after cardiac arrest (CA). A decrease in antioxidant defenses may contribute to\n                    <jats:sc>I\/R<\/jats:sc>\n                    injury. The present study aims to investigate the influence of mild therapeutic hypothermia (MTH) on levels of nonenzymatic antioxidants after CA. We investigated antioxidant levels at 6, 12, 36, and 72 hours after CA in central venous blood samples of patients admitted to intensive care. The sample consisted of 31 patients under controlled normothermia (36\u00b0C) and 11 patients treated with 24 hours of MTH (33\u00b0C). Erythrocyte glutathione (GSH) levels were elevated by MTH, increasing at 6, 12, 36, and 72 hours after CA in hypothermic patients (mean GSH levels in normothermic patients: 6 hours\u2009=\u200973.89, 12 hours\u2009=\u200956.45, 36 hours\u2009=\u200956.46, 72 hours\u2009=\u200961.80 vs. hypothermic patients: 6 hours\u2009=\u2009176.89, 12 hours\u2009=\u2009198.78, 36 hours\u2009=\u2009186.96, and 72 hours\u2009=\u2009173.68\u2009\u03bcmol\/g of protein). Vitamin C levels decreased significantly at 6 and 12 hours after CA in hypothermic patients (median vitamin C levels in normothermic patients: 6 hours\u2009=\u20097.53, 12 hours\u2009=\u20099.40, 36 hours\u2009=\u20098.56, and 72 hours\u2009=\u20098.51 vs. hypothermic patients: 6 hours\u2009=\u20095.46, 12 hours\u2009=\u20095.44, 36 hours\u2009=\u20096.10, and 72 hours\u2009=\u20095.89\u2009mmol\/L), coinciding with the period of therapeutic hypothermia. Vitamin E and nitric oxide levels were not altered by hypothermic treatment. These findings suggest that MTH alters nonenzymatic antioxidants differently, decreasing circulating vitamin C levels during treatment; however, MTH elevates GSH levels, possibly protecting tissues from\n                    <jats:sc>I\/R<\/jats:sc>\n                    injury after CA.\n                  <\/jats:p>","DOI":"10.1089\/ther.2018.0012","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T12:04:46Z","timestamp":1531915486000},"page":"63-69","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Mild Therapeutic Hypothermia Increases Glutathione Levels in Postcardiac Arrest Patients"],"prefix":"10.1177","volume":"9","author":[{"given":"Fernanda S.","family":"Hackenhaar","sequence":"first","affiliation":[{"name":"UFRGS","place":["Brazil"]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00e1ssia M.","family":"Medeiros","sequence":"additional","affiliation":[{"name":"UFRGS","place":["Brazil"]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda M.","family":"Heemann","sequence":"additional","affiliation":[{"name":"UFRGS","place":["Brazil"]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camile S.","family":"Behling","sequence":"additional","affiliation":[{"name":"UFRGS","place":["Brazil"]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila D.","family":"Mahl","sequence":"additional","affiliation":[{"name":"UFRGS","place":["Brazil"]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleber","family":"Verona","sequence":"additional","affiliation":[{"name":"UFRGS","place":["Brazil"]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular","place":["Brazil"]},{"name":"Grupo Hospitalar Concei\u00e7\u00e3o","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina A.","family":"Silva","sequence":"additional","affiliation":[{"name":"UFRGS","place":["Brazil"]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Martins","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Grupo Hospitalar Concei\u00e7\u00e3o","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego F. M.","family":"Riveiro","sequence":"additional","affiliation":[{"name":"Grupo Hospitalar Concei\u00e7\u00e3o","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia R. R.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara S.","family":"Benfato","sequence":"additional","affiliation":[{"name":"UFRGS","place":["Brazil"]},{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Biologia Celular e Molecular","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,8]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2015.04.025"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00416-0"},{"key":"e_1_3_4_4_1","first-page":"6891536","article-title":"Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children","volume":"37","author":"Bayir H","year":"2009","unstructured":"Bayir H, , Adelson DP, , Wisniewski SR. Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children. Crit Care Med, 2009; 37:6891536.","journal-title":"Crit Care Med"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01891.x"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.04.026"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3170"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/562429"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182a276e8"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035313"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4002"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(96)68026-4"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-014-0070-6"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8704352"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198717478.001.0001"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9040339"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182186d42"},{"key":"e_1_3_4_19_1","first-page":"362","article-title":"Simultaneous determination of ascorbic acid and free malondialdehyde in human serum by HPLC-UV","volume":"22","author":"Karatepe M.","year":"2004","unstructured":"Karatepe M. Simultaneous determination of ascorbic acid and free malondialdehyde in human serum by HPLC-UV. LC GC N Am, 2004; 22:362\u2013365.","journal-title":"LC GC N Am"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00406-4"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31822ef9e4"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/yea.1817"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.09.017"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-124"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.01.053"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-007-0555-7"},{"key":"e_1_3_4_27_1","doi-asserted-by":"crossref","unstructured":"Taniguchi N Gutteridge J. Experimental Protocols for Reactive Oxygen and Nitrogen Species. Oxford-UK: Oxford University Press 2000.","DOI":"10.1093\/oso\/9780198506683.001.0001"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.11.006"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.09.031"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2011.05.022"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2009.06.007"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760600602902"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.16.2007"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.02.013"},{"key":"e_1_3_4_35_1","first-page":"194","article-title":"Effects of mild hypothermia therapy on the levels of glutathione in rabbit blood and cerebrospinal fluid after cardiopulmonary resuscitation","volume":"18","author":"Zhao H","year":"2015","unstructured":"Zhao H, , Chen YL. Effects of mild hypothermia therapy on the levels of glutathione in rabbit blood and cerebrospinal fluid after cardiopulmonary resuscitation. Iran J Basic Med Sci, 2015; 18:194\u2013198.","journal-title":"Iran J Basic Med Sci"}],"container-title":["Therapeutic Hypothermia and Temperature Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ther.2018.0012","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ther.2018.0012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ther.2018.0012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:24:59Z","timestamp":1777699499000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ther.2018.0012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,3,1]]}},"alternative-id":["10.1089\/ther.2018.0012"],"URL":"https:\/\/doi.org\/10.1089\/ther.2018.0012","relation":{},"ISSN":["2153-7658","2153-7933"],"issn-type":[{"value":"2153-7658","type":"print"},{"value":"2153-7933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,1]]}}}