{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:08:11Z","timestamp":1777939691401,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:p>\n                    Target Temperature Management (TTM) is standard care following out of hospital cardiac arrest (OHCA). The aim of the study was to evaluate if treatment temperature (33\u00b0C or 36\u00b0C) or other predefined variables were associated with the occurrence of bleeding in the TTM study. This study is a predefined,\n                    <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                    analysis of the TTM trial, a multinational randomized controlled trial comparing treatment at 33\u00b0C and 36\u00b0C for 24 hours after OHCA with return of spontaneous circulation. Bleeding events from several locations were registered daily. The main outcome measure was occurrence of any bleeding during the first 3 days of intensive care. Risk factors for bleeding, including temperature allocation, were evaluated. Complete data were available for 722\/939 patients. Temperature allocation was not associated with bleeding either in the univariable (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.95) or in the primary multivariable analysis (odds ratio [OR] 0.95; 95% confidence interval [CI] 0.64\u20131.41,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.80). A multiple imputation model, including all patients, was used as a sensitivity analysis, rendering similar results (OR 0.98; 95% CI 0.69\u20131.38,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.92). Factors associated with bleeding were increasing age, female sex, and angiography with percutaneous coronary intervention (PCI) within 36 hours of cardiac arrest (CA) in both the primary and the sensitivity analysis. TTM at 33\u00b0C, when compared to TTM at 36\u00b0C, was not associated with an increased incidence of bleeding during the first 3 days of intensive care after CA. Increasing age, female gender, and PCI were independently associated with any bleeding the first 3 days after CA.\n                  <\/jats:p>","DOI":"10.1089\/ther.2018.0024","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T07:38:00Z","timestamp":1544168280000},"page":"177-183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Bleeding Complications After Cardiac Arrest and Targeted Temperature Management, a\n                    <i>Post Hoc<\/i>\n                    Study of the Targeted Temperature Management Trial"],"prefix":"10.1177","volume":"9","author":[{"given":"Thomas","family":"Kander","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Anesthesia and Intensive Care, Skane University Hospital, Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susann","family":"Ull\u00e9n","sequence":"additional","affiliation":[{"name":"Clinical Studies Sweden\u2014Forum South Skane University Hospital, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Dankiewicz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Skane University Hospital, Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt P.","family":"Wise","sequence":"additional","affiliation":[{"name":"Adult Critical Care, University Hospital of Wales, Cardiff, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Sch\u00f6tt","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Anesthesia and Intensive Care, Skane University Hospital, Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malin","family":"Rundgren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Anesthesia and Intensive Care, Skane University Hospital, Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003289"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v045.i03"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4709-0"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12235"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31817340ad"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00828.x"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199806000-00022"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.05.046"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH17-03-0176"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615947"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-7-2"},{"key":"e_1_3_3_13_1","first-page":"e15","article-title":"A sensitivity comparison of the Quick and Owren prothrombin time methods in oral anticoagulant therapy","volume":"2","author":"Horsti J","year":"2009","unstructured":"Horsti J. 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