{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:08:12Z","timestamp":1777939692284,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:p>\n                    The objective of this study was to determine a risk factor for predicting bacterial infection in patients, who survived out-of-hospital cardiac arrest (OHCA), during targeted temperature management (TTM). This prospective registry-based retrospective observational study was conducted from November 2010 to October 2017. We measured several biomarkers such as whole blood cell counts, and levels of C-reactive protein and procalcitonin daily during TTM. The primary outcome was bacterial growth in initial blood or sputum cultures. A total of 116 patients were analyzed in this study. The bacterial growth rate was 32.8% and the procalcitonin levels measured at 24\u2009h from cardiac arrest was significantly higher in the culture-positive group than the culture-negative group (10.6 vs. 2.5\u2009ng\/mL,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.017). Area under the receiver operating characteristic curve for procalcitonin obtained after 24\u2009h was 0.727 and the cutoff value was 6.5\u2009ng\/mL (odds ratio 9.58 [95% confidential interval, CI 2.21\u201341.55],\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.003). Sensitivity was 71.4% [95% CI 41.9\u201391.6] and specificity was 79.3% [95% CI 60.3\u201392.0]. Procalcitonin measured at 24\u2009h from cardiac arrest was associated with bacterial infection in OHCA patients undergoing TTM. Further prospective interventional studies are needed to validate these results.\n                  <\/jats:p>","DOI":"10.1089\/ther.2018.0033","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T10:18:39Z","timestamp":1545387519000},"page":"190-196","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors Predicting Bacterial Infection in Out-of-Hospital Cardiac Arrest Patients Undergoing Targeted Temperature Management"],"prefix":"10.1177","volume":"9","author":[{"given":"Seung Mok","family":"Ryoo","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Joon","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungmin","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Hwan","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0B013E318165BABB"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003289"},{"key":"e_1_3_2_4_1","first-page":"362","article-title":"Post-cardiac arrest syndrome","volume":"76","author":"Binks A","year":"2010","unstructured":"Binks A, , Nolan JP. 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