{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:23:28Z","timestamp":1791080608982,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:p>\n                    Cerebral oximetry using near-infrared spectroscopy (NIRS) provides continuous, noninvasive assessment of the degree of hemoglobin saturation of the brain tissue. Previous studies suggest that high values of regional cerebral tissue oxygen saturation (rScO\n                    <jats:sub>2<\/jats:sub>\n                    ) during the first days in neonates with significant hypoxic\u2013ischemic encephalopathy (HIE) are correlated with an adverse neurological outcome. However, the results are not consistent among the studies. To examine the correlation of rScO\n                    <jats:sub>2<\/jats:sub>\n                    values and their variability over time with HIE severity, amplitude integrated electroencephalography (aEEG) background and seizure activity, neuron-specific enolase levels in cerebrospinal fluid, magnetic resonance imaging (MRI) findings, and neurological outcome. Retrospective study that included all consecutive infants with moderate-to-severe HIE born at \u226535 weeks gestational age admitted between January 2011 and December 2014. NIRS monitoring was initiated at admission and maintained during therapeutic hypothermia up to 12 hours after rewarming. To analyze rScO\n                    <jats:sub>2<\/jats:sub>\n                    , different periods (0\u20136, 6\u201324, 24\u201348, 48\u201372, and 72\u2013100 hours of life) and three ranges (&lt;55%, 55\u201390%, &gt;90%) were considered. Variability in each patient was considered \u22645% when changes in rScO\n                    <jats:sub>2<\/jats:sub>\n                    values in all periods were \u22645%. Twenty-three newborns were included. Infants who suffered from severe HIE, seizures, abnormal aEEG background, altered MRI or death, and abnormal outcome had rScO\n                    <jats:sub>2<\/jats:sub>\n                    values &gt;90% and with less variability (\u22645%). rScO\n                    <jats:sub>2<\/jats:sub>\n                    values &gt;90% and a lack of variability over time in infants with HIE during cooling provide useful information about the severity of neurological status.\n                  <\/jats:p>","DOI":"10.1089\/ther.2018.0041","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T11:20:12Z","timestamp":1548328812000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Lack of Variability in Cerebral Oximetry Tendency in Infants with Severe Hypoxic\u2013Ischemic Encephalopathy Under Hypothermia"],"prefix":"10.1177","volume":"9","author":[{"given":"Mar\u00eda","family":"Arriaga-Redondo","sequence":"first","affiliation":[{"name":"Neonatology Division, Gregorio Mara\u00f1\u00f3n Hospital, Madrid, Spain."},{"name":"Fundaci\u00f3n NeNe, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Arnaez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n NeNe, Madrid, Spain."},{"name":"Neonatology Division, Burgos University Hospital, Burgos, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Benavente-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n NeNe, Madrid, Spain."},{"name":"Neonatology Division, Puerta del Mar University Hospital, C\u00e1diz, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sim\u00f3n","family":"Lubi\u00e1n-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n NeNe, Madrid, Spain."},{"name":"Neonatology Division, Puerta del Mar University Hospital, C\u00e1diz, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montesclaros","family":"Hortig\u00fcela","sequence":"additional","affiliation":[{"name":"Neuropediatric Division, Burgos University Hospital, Burgos, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Vega-del-Val","sequence":"additional","affiliation":[{"name":"Neonatology Division, Burgos University Hospital, Burgos, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Garcia-Alix","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n NeNe, Madrid, Spain."},{"name":"Institut de Recerca Pediatrica Sant Joan de D\u00e8u, Sant Joan de D\u00e8u Hospital, Passeig Sant Joan de D\u00e9u, Barcelona, Spain."},{"name":"Universitat de Barcelona, Barcelona, Spain."},{"name":"CIBER de Enfermedades Raras (CIBERER), Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,12,5]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/bmte.2000.45.11.328"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.09.008"},{"key":"e_1_3_4_4_1","first-page":"339","article-title":"Cerebral, renal, and splanchnic tissue oxygen saturation values in healthy term newborns","volume":"31","author":"Bailey SM","year":"2014","unstructured":"Bailey SM, , Hendricks-Munoz KD, , Mally P. 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