{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:08:20Z","timestamp":1777939700171,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:p>\n                    This study aims to quantify the extent of electrolyte (potassium, magnesium, and phosphorus) and blood glucose changes during targeted temperature management (TTM), with insight on electrolyte replacements and insulin administration. This was a 3-year retrospective study of patients who underwent TTM via Arctic Sun. Electrolyte and blood glucose values in addition to electrolyte replacements and insulin administrations were collected before, during, and post-TTM. The primary analysis assessed changes in electrolyte and blood glucose values during and after TTM, and the secondary analysis assessed changes before and during, and before and after TTM. The secondary analysis also incorporated amount of electrolyte replacements and insulin administrations patients received before, during, and post-TTM. Sixty patients were included for analysis. Comparing levels during to after TTM, there was a significant increase in potassium (3.7 [0.7]\u20134.4 [0.7] mmol\/L,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and decrease in blood glucose (192 [135]\u2013134 [55] mg\/dL,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.001). Comparing levels before to during TTM, there was a significant decrease in potassium (4.3 [0.7]\u20133.7 [0.7] mmol\/L,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and phosphorus (4.8 [3.2]\u20133.4 [1.5] mg\/dL,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.003). Comparing levels before to after TTM, there was a significant decrease in phosphorus (4.5 [2.9]\u20133.3 [1.2] mmol\/L,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.026) and blood glucose (219 [35]\u2013134 [55] mg\/dL,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Patients received on average potassium 102 mEq, magnesium 1.9\u2009g, phosphorus 9\u2009mmol, and insulin 94 units. Potassium significantly decreased during and significantly increased after TTM. Phosphorus significantly decreased during TTM and blood glucose significantly decreased after TTM. There were no significant changes in magnesium during the defined time period.\n                  <\/jats:p>","DOI":"10.1089\/ther.2018.0044","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T14:25:03Z","timestamp":1565187903000},"page":"76-81","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Targeted Temperature Management: Quantifying the Extent of Serum Electrolyte and Blood Glucose Shifts in Postcardiac Arrest Patients"],"prefix":"10.1177","volume":"10","author":[{"given":"Christina","family":"Xie","sequence":"first","affiliation":[{"name":"Regional Medical Center of San Jose, San Jose, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Basken","sequence":"additional","affiliation":[{"name":"Banner University Medical Center\u2014Tucson, Tucson, Arizona."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Finger","sequence":"additional","affiliation":[{"name":"Banner University Medical Center\u2014Tucson, Tucson, Arizona."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Erstad","sequence":"additional","affiliation":[{"name":"University of Arizona College of Pharmacy, Tucson, Arizona."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.1.102"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003289"},{"issue":"2","key":"e_1_3_3_4_1","first-page":"S465","article-title":"Part 8: Post-Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care","volume":"132","author":"Callaway CW","year":"2015","unstructured":"Callaway CW, , Donnino MW, , Fink EL, et al. Part 8: Post-Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation, 2015; 132(18 Suppl 2):S465\u2013S482.","journal-title":"Circulation"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-010-9474-7"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31822572c9"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2015.69.157-160"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941874413519802"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01691254"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ther.2014.0012"},{"key":"e_1_3_3_11_1","unstructured":"Medivance. Arctic Sun 5000 Temperature Management System. www.medivance.com\/ArcticSun5000 Accessed July2 2017."},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.08.007"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.10.034"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310519"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-3025"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181962ad5"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.94.5.0697"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11283"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/ther.2012.0004"},{"key":"e_1_3_3_20_1","first-page":"1","article-title":"Main complications of mild induced hypothermia after cardiac arrest: a review article","volume":"6","author":"Soleimanpout H","year":"2014","unstructured":"Soleimanpout H, , Rahmani F, , Golzari SE, , Safari S. Main complications of mild induced hypothermia after cardiac arrest: a review article. J Cardiovasc Thorac Res, 2014; 6:1\u20138.","journal-title":"J Cardiovasc Thorac Res"},{"issue":"4","key":"e_1_3_3_21_1","first-page":"S69","article-title":"Potassium correction of hypothermic hypokalemia induces hyperkalemia after rewarming","volume":"27","author":"Sprung J","year":"1990","unstructured":"Sprung J, , Gamulin S, , Bosnjak ZJ, , Kampine JP. Potassium correction of hypothermic hypokalemia induces hyperkalemia after rewarming. Can J Anaesth, 1990; 27(4 Pt2):S69.","journal-title":"Can J Anaesth"},{"key":"e_1_3_3_22_1","unstructured":"StataCorp. Stata Statistical Software: Release 15. 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