{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:11:38Z","timestamp":1779185498323,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:p>\n                    Targeted temperature management (TTM) might improve outcome of patients with severe subarachnoid hemorrhage (SAH) in which vasospasm, delayed cerebral ischemia (DCI), and increased intracranial pressure (ICP) are frequent and severe complications. A series of patients (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20093) with severe aneurysmatic SAH were treated by TTM if they developed ICP crisis and\/or severe vasospasm diagnosed by angiography. Once these complications were detected, body core temperature (BCT) was rapidly decreased to 35\u00b0C or 33\u00b0C, if necessary. BCT induced and maintained by surface cooling remained at the desired level for at least 72 hours. Rewarming was performed by 1\u00b0C, only if the target parameters ICP and velocities in the serial Doppler sonography indicating macrovascular vasospasm improved to regular levels. In case of increase of ICP or middle cerebral arteries velocities BCT was decreased again to the last effective level. The patients developed vasospasm between days 6 and 12 after SAH. All aneurysms were treated by coiling. BCT was reduced between days 6 and 12 after SAH. Total duration of BCT &lt;36.5\u00b0C was between 5.5 and 8 days. It remained &lt;35\u00b0C for 4\u20136 days, and at 33\u00b0C for 3 days on average. ICP could be sufficiently controlled in all patients, because no ICP crisis was observed during TTM and after rewarming. Two patients developed minor DCI. Side effects of prolonged ventilation of 7\u201318 days included pneumonia for two patients that could be treated sufficiently. Other complications were one case of ventriculitis and two temporary deliriums. Outcome of the patients was good because no focal neurological symptoms could be detected after rehabilitation. TTM represents a promising treatment approach for severe SAH in which standard treatment is often limited and experimental. It deserves further clinical investigation in a larger cohort.\n                  <\/jats:p>","DOI":"10.1089\/ther.2018.0049","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T10:49:23Z","timestamp":1553597363000},"page":"216-221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Targeted Temperature Management for Subarachnoid Hemorrhage: Excellent Outcome After Severe Vasospasm\u2014A Case Series"],"prefix":"10.1177","volume":"9","author":[{"given":"Lisa","family":"M\u00e4der","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Neurologie und Neurointensivmedizin, Klinikum Darmstadt, Darmstadt, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajaz","family":"Ganai","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie und Neurointensivmedizin, Klinikum Darmstadt, Darmstadt, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilia","family":"Aroyo","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie und Neurointensivmedizin, Klinikum Darmstadt, Darmstadt, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Schill","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie und Neurointensivmedizin, Klinikum Darmstadt, Darmstadt, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Tr\u00f6scher-Weber","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Radiologie, Neuroradiologie und Nuklearmedizin, Klinikum Darmstadt, Darmstadt, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Huppert","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Radiologie, Neuroradiologie und Nuklearmedizin, Klinikum Darmstadt, Darmstadt, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Kotterer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Radiologie, Neuroradiologie und Nuklearmedizin, Klinikum Darmstadt, Darmstadt, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Geletneky","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurochirurgie, Klinikum Darmstadt, Darmstadt, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Kollmar","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie und Neurointensivmedizin, Klinikum Darmstadt, Darmstadt, Germany."},{"name":"University Hospital Erlangen, Erlangen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2018.04.001"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4702-y"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1987.253.4.H869"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.8.1337"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2008.00168.x"},{"key":"e_1_3_2_7_1","first-page":"21","article-title":"Prediction of symptomatic vasospasmafter subarachnoid hemorrhage: The modified fisher scale","volume":"59","author":"Frontera JA","year":"2006","unstructured":"Frontera JA, , Claassen J, , Schmidt JM, et al. 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