{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:08:35Z","timestamp":1777939715437,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:p>\n                    The beneficial effect of sinus bradycardia during targeted temperature management (TTM) in cardiac arrest patients remains doubtful. We aimed to investigate the impact of sinus bradycardia on survival and neurological outcome. MEDLINE (PubMed), Cochrane, Google Scholar, and\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    databases were searched for studies reporting on comatose postcardiac arrest patients presenting sinus bradycardia during TTM. Outcomes were the 180-day survival and final neurologic function assessed by the Cerebral Performance Category scale. The effect size on study outcomes is presented as odds ratio (OR) with 95% confidence interval (CI). Two studies with 681 patients were included. Compared to no-sinus bradycardia group, in patients with sinus bradycardia below 50\u2009bpm, a significant effect of sinus bradycardia on reduction of 180-day mortality was reported (OR\u2009=\u20090.42; 95% CI: 0.29\u20130.59). No heterogeneity was detected. Sinus bradycardia below 50\u2009bpm during TTM may be protective and should be considered in comatose postcardiac arrest patients.\n                  <\/jats:p>","DOI":"10.1089\/ther.2019.0027","type":"journal-article","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T10:50:47Z","timestamp":1572346247000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Sinus Bradycardia During Targeted Temperature Management: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"10","author":[{"given":"Evdoxia","family":"Kyriazopoulou","sequence":"first","affiliation":[{"name":"Postgraduate Study Program (MSc) \u201cCardiopulmonary Resuscitation,\u201d Medical School, National and Kapodistrian University of Athens, Athens, Greece."},{"name":"4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Karakike","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Ekmektzoglou","sequence":"additional","affiliation":[{"name":"Postgraduate Study Program (MSc) \u201cCardiopulmonary Resuscitation,\u201d Medical School, National and Kapodistrian University of Athens, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miltiades","family":"Kyprianou","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraskevas","family":"Gkolfakis","sequence":"additional","affiliation":[{"name":"Hepatogastroenterology Unit, 2nd Department of Internal Medicine-Propaedeutic Research Institute and Diabetes Center, National and Kapodistrian University of Athens, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Chalkias","sequence":"additional","affiliation":[{"name":"Postgraduate Study Program (MSc) \u201cCardiopulmonary Resuscitation,\u201d Medical School, National and Kapodistrian University of Athens, Athens, Greece."},{"name":"Faculty of Medicine, Department of Anesthesiology, University of Thessaly, Larisa, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Kouskouni","sequence":"additional","affiliation":[{"name":"Postgraduate Study Program (MSc) \u201cCardiopulmonary Resuscitation,\u201d Medical School, National and Kapodistrian University of Athens, Athens, Greece."},{"name":"Department of Biopathology, Medical School, Aretaieio Hospital, National and Kapodistrian University of Athens, Athens, Greece."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoros","family":"Xanthos","sequence":"additional","affiliation":[{"name":"Postgraduate Study Program (MSc) \u201cCardiopulmonary Resuscitation,\u201d Medical School, National and Kapodistrian University of Athens, Athens, Greece."},{"name":"Department of Physiology and Pathophysiology, School of Medicine, European University Cyprus, Nicosia, Cyprus."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-6757(86)90255-X"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000543"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2018.04.037"},{"key":"e_1_3_4_5_1","first-page":"213","article-title":"2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. 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