{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:08:34Z","timestamp":1777939714092,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:p>\n                    In several studies, regional cerebral oxygen saturation (rSO\n                    <jats:sub>2<\/jats:sub>\n                    ) has been measured in patients with postcardiac arrest syndrome (PCAS) to analyze the brain's metabolic status. However, the significance of rSO\n                    <jats:sub>2<\/jats:sub>\n                    in PCAS patients remains unclear. In the present study, we investigated the relationship between rSO\n                    <jats:sub>2<\/jats:sub>\n                    and physiological parameters. Comatose survivors of out-of-hospital PCAS with targeted temperature management (TTM) at 34\u00b0C for 24 hours were included. All patients were monitored for their rSO\n                    <jats:sub>2<\/jats:sub>\n                    and additional parameters (arterial oxygen saturation [SaO\n                    <jats:sub>2<\/jats:sub>\n                    ], hemoglobin [Hb], mean arterial pressure [MAP], arterial carbon dioxide pressure [PaCO\n                    <jats:sub>2<\/jats:sub>\n                    ], and body temperature]) measured at the start of monitoring and 24 and 48 hours after return of spontaneous circulation (ROSC). Patients were divided into favorable and unfavorable groups, and the correlation between rSO\n                    <jats:sub>2<\/jats:sub>\n                    and these physiological parameters was evaluated by multiple regression analysis. Forty-nine patients were included in the study, with 15 in the favorable group and 34 in the unfavorable group. There was no significant difference in the rSO\n                    <jats:sub>2<\/jats:sub>\n                    value between the two groups at any time point. The multiple regression analysis of the favorable group revealed a moderate correlation between rSO\n                    <jats:sub>2<\/jats:sub>\n                    and SaO\n                    <jats:sub>2<\/jats:sub>\n                    , Hb, and PaCO\n                    <jats:sub>2<\/jats:sub>\n                    only at 24 hours (coefficients: 0.482, 0.422, and 0.531, respectively), whereas that of the unfavorable group revealed moderate correlations between rSO\n                    <jats:sub>2<\/jats:sub>\n                    and Hb values at all time points, PaCO\n                    <jats:sub>2<\/jats:sub>\n                    at 24 hours and MAP at 24 and 48 hours. rSO\n                    <jats:sub>2<\/jats:sub>\n                    was moderately correlated to MAP in unfavorable patients. To optimize brain oxygen metabolic balance for PCAS patients with TTM measuring rSO\n                    <jats:sub>2<\/jats:sub>\n                    , we suggest total evaluation of each parameters of SaO\n                    <jats:sub>2<\/jats:sub>\n                    , Hb, MAP, and PaCO\n                    <jats:sub>2<\/jats:sub>\n                    .\n                  <\/jats:p>","DOI":"10.1089\/ther.2019.0032","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T11:04:31Z","timestamp":1576062271000},"page":"71-75","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Parameters Influencing Brain Oxygen Measurement by Regional Oxygen Saturation in Postcardiac Arrest Patients with Targeted Temperature Management"],"prefix":"10.1177","volume":"10","author":[{"given":"Atsushi","family":"Sakurai","sequence":"first","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Ihara","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumi","family":"Tagami","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsunori","family":"Sugita","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Kuwana","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nami","family":"Sawada","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hori","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Taniguch","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Nihon University School of Medicine, Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosaku","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Division of Emergency and Critical Care Medicine, Department of Acute Medicine, Nihon University School of Medicine, Tokyo, 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