{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:07:28Z","timestamp":1787162848090,"version":"build-2736575974"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:p>Rapid induction and maintaining a target temperature of 32.0\u201336.0\u00b0C within a narrow range for &lt;24 hours are essential, but those are very hard to perform in postcardiac arrest syndrome (PCAS) patients. We investigated the usability of an intravascular temperature management (IVTM) system with neurolept-anesthesia (NLA; droperidol and fentanyl). Single-arm, prospective multicenter trial was carried out in the seven university and the three affiliated hospitals. In the 24 comatose PCAS patients, the target temperature (33.0\u00b0C) was rapidly induced and maintained for 24 hours using an IVTM system with NLA. The rewarming speed was 0.1\u00b0C\/h until 36.5\u00b0C and was maintained for 24 hours. The primary end point was the ability to achieve \u226434.0\u00b0C for &lt;3 hours after starting cooling, and the secondary end points were the cooling rate, deviation from the target temperature, and adverse events. Cerebral Performance Category (CPC) score at 14 days was also evaluated. Statistical analyses were performed by SPSS software, using the intention-to-treat data sets. The target temperature of \u226434.0\u00b0C was reached by 45 minutes (35\u201373 minutes) and was within 3 hours in all patients. The cooling rate from 36.4\u00b0C to 33.0\u00b0C was 2.7\u00b0C\/h (2.4\u20133.6\u00b0C\/h). The temperature of 33.1\u00b0C (33.1\u201333.1\u00b0C) and 36.7\u00b0C (36.6\u201336.9\u00b0C) for 24 hours each was held during the maintenance and the after rewarming phases, respectively. Temperature deviations &gt;0.2\u00b0C from 33.0\u00b0C in the maintenance phase occurred once each in two patients. The favorable neurological outcomes (CPC1, 2) were relatively good (50%). Five patients experienced serious adverse events; none was device related. We rapidly achieved therapeutic hypothermia within a narrow temperature range without major complications using the IVTM system with NLA in PCAS patients.<\/jats:p>","DOI":"10.1089\/ther.2019.0046","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T17:59:08Z","timestamp":1588183148000},"page":"179-185","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Precision and Safety of an Intravascular Temperature Management System for Postcardiac Arrest Syndrome Patients: A Multicenter Clinical Trial (COOL-ARREST JP)"],"prefix":"10.1177","volume":"10","author":[{"given":"Tsuyoshi","family":"Maekawa","sequence":"first","affiliation":[{"name":"Yamaguchi Prefectural University, Yamaguchi, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Advanced Medical Emergency and Critical Care 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