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The practicality, effectiveness, and safety of this system were clinically tested in our initial series of 14 patients with severe head injuries. The patients were randomized into two groups: direct brain cooling at 32\u00b0C and the control group. All of them received intracranial pressure (ICP), focal brain oxygenation, brain temperature, and direct cortical brainwave monitoring. The direct brain cooling group did better in the Extended Glasgow Outcome Scale at the time of discharge and at 6 months after trauma. This could be owing to a trend in the monitored parameters; reduction in ICP, increment in cerebral perfusion pressure, optimal brain redox regulation, near-normal brain temperature, and lessening of epileptic-like brainwave activities are likely the reasons for better outcomes in the cooling group. Finally, this study depicts interesting cortical brainwaves during a transition time from being alive to dead. It is believed that the demonstrated cortical brainwaves follow the principles of quantum physics.<\/jats:p>","DOI":"10.1089\/ther.2020.0033","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T16:16:47Z","timestamp":1611937007000},"page":"103-114","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["A Clinical Test for a Newly Developed Direct Brain Cooling System for the Injured Brain and Pattern of Cortical Brainwaves in Cooling, Noncooling, and Dead Brain"],"prefix":"10.1177","volume":"12","author":[{"given":"Zamzuri","family":"Idris","sequence":"first","affiliation":[{"name":"Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia."},{"name":"Brain and Behaviour Cluster (BBC), School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia."},{"name":"Hospital Universiti Sains Malaysia (HUSM), Universiti Sains Malaysia, Kubang Kerian, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang Song","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia."},{"name":"Hospital Universiti Sains Malaysia (HUSM), Universiti Sains Malaysia, Kubang Kerian, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Mohd Nazaruddin","family":"Wan Hassan","sequence":"additional","affiliation":[{"name":"Hospital Universiti Sains Malaysia (HUSM), Universiti Sains Malaysia, Kubang Kerian, Malaysia."},{"name":"Department of Anaesthesiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Hasyizan","family":"Hassan","sequence":"additional","affiliation":[{"name":"Hospital Universiti Sains Malaysia (HUSM), Universiti Sains Malaysia, Kubang Kerian, Malaysia."},{"name":"Department of Anaesthesiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khairu Anuar","family":"Mohd Zain","sequence":"additional","affiliation":[{"name":"Collaborative Microelectronic Design Excellence Center (CEDEC), Universiti Sains Malaysia, Bayan Lepas, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asrulnizam","family":"Abdul Manaf","sequence":"additional","affiliation":[{"name":"Collaborative Microelectronic Design Excellence Center (CEDEC), Universiti Sains Malaysia, Bayan Lepas, Malaysia."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2016.05.004"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002376"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2006.07.012"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.05.030"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308285110"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200102223440803"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70300-8"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002205"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.077"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000114513.96704.29"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-007-0068-y"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.21315\/mjms2020.27.1.1"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/1793-5482.131058"},{"key":"e_1_3_3_15_1","doi-asserted-by":"crossref","unstructured":"Idris Z WM Nazaruddin WH Mustapha M et al. 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