{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:09:03Z","timestamp":1777939743850,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p>\n                    We examined the association between variability in body temperature (BT) and water temperature (WT) during the maintenance period of targeted temperature management (TTM) and neurologic outcomes in out-of-hospital cardiac arrest (OHCA) survivors. Adult (\u226518 years), comatose OHCA survivors who underwent TTM at 33\u00b0C between October 2015 and December 2019 were included. We collected data on BT and WT recorded every minute during the TTM maintenance period. Temperature variability was measured as the standard deviation of BT and WT during the 33\u00b0C maintenance period. The primary outcome was a poor neurologic outcome, defined as a cerebral performance category scale 3\u20135 at 6 months. Of the 154 included patients, 96 (62.3%) had poor outcomes. The BT variability in the poor outcome group was lower than that in the good outcome group (0.16\u00b0C [0.13\u20130.27\u00b0C] vs. 0.13\u00b0C [0.11\u20130.18\u00b0C]). In addition, the WT variability during the maintenance period in the poor outcome group was lower than that in the good outcome group (2.24\u00b0C [1.80\u20133.96\u00b0C] vs. 1.77\u00b0C [1.26\u20132.32\u00b0C]). In the multivariate analysis, WT variability (odds ratio 0.508; 95% confidence interval, 0.295\u20130.874;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.014) was independently associated with poor neurologic outcome. BT variability and cooling beyond 33.0\u00b0C\u2009\u00b1\u20091.0\u00b0C were not associated with poor neurologic outcomes. WT variability during the maintenance period was independently associated with neurologic outcomes in OHCA survivors who underwent TTM at 33\u00b0C. In addition, overcooling or undercooling during the maintenance period was not associated with neurologic outcomes.\n                  <\/jats:p>","DOI":"10.1089\/ther.2021.0011","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T21:49:56Z","timestamp":1626472196000},"page":"74-81","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Water Temperature Variability Is Associated with Neurologic Outcomes in Out-of-Hospital Cardiac Arrest Survivors Who Underwent Targeted Temperature Management at 33\u00b0C"],"prefix":"10.1177","volume":"12","author":[{"given":"Seok Jin","family":"Ryu","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University, Chonnam National University Hospital, Gwangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University, Chonnam National University Hospital, Gwangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3571-9448","authenticated-orcid":false,"given":"Byung Kook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University, Chonnam National University Hospital, Gwangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Woon","family":"Jeung","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University, Chonnam National University Hospital, Gwangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Hun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University, Chonnam National University Hospital, Gwangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4283-5423","authenticated-orcid":false,"given":"Jung Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea."},{"name":"Department of Emergency Medicine, College of Medicine, Chungnam National University, Daejeon, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hong","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chonnam National University, Chonnam National University Hospital, Gwangju, Republic of Korea."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066610384061"},{"key":"e_1_3_4_3_1","first-page":"184","article-title":"Cardiopulmonary bypass for resuscitation of patients with accidental hypothermia and cardiac arrest","volume":"35","author":"Baumgartner FJ","year":"1992","unstructured":"Baumgartner FJ, , Janusz MT, , Jamieson WR, et al. Cardiopulmonary bypass for resuscitation of patients with accidental hypothermia and cardiac arrest. Can J Surg, 1992; 35:184\u2013187.","journal-title":"Can J Surg"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13616"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.7.870"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079589"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1114208"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000262"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/ther.2020.0005"},{"key":"e_1_3_4_11_1","first-page":"1070","article-title":"A retrospective analysis of air-evacuated hypothermia patients","volume":"59","author":"Fox JB","year":"1988","unstructured":"Fox JB, , Thomas F, , Clemmer TP, et al. A retrospective analysis of air-evacuated hypothermia patients. 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