{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:09:02Z","timestamp":1777939742281,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p>\n                    We aimed to evaluate the effect of prolonged targeted temperature management (TTM) in patients with out-of-hospital cardiac arrest (OHCA) on the levels of midregional pro-atrial natriuretic peptide (MR-proANP) and N-terminal pro b-type natriuretic peptide (NT-proBNP) and assess their potential as prognostic biomarkers. A preplanned\n                    <jats:italic toggle=\"yes\">post hoc<\/jats:italic>\n                    analysis of \u201cTargeted temperature management for 48\u2009h vs 24\u2009h and neurologic outcome after out-of-hospital cardiac arrest: A randomized clinical trial (TTH48 trial),\u201d where patients were randomized to TTM at 33\u00b0C\u2009\u00b1\u20091\u00b0C of standard duration (24 hours) versus prolonged (48 hours). Blood samples were drawn from patients with OHCA at two Scandinavian university hospitals at admission to the ICU and at 24, 48, and 72 hours after reaching the target temperature. Primary outcome was levels of MR-proANP and NT-proBNP. Secondary outcome was cerebral performance category (CPC 1\u20135) at 6 months. Samples from 114 patients were analyzed. Prolonged TTM significantly decreased the levels of MR-proANP and NT-proBNP at 48 hours compared with standard 24 hours-TTM (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01). However, there were no significant differences at other time points. Patients with poor outcome (CPC 3\u20135) had a statistically significantly increased MR-proANP level at 24 hours (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and 72 hours (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.01) compared with the good outcome group (CPC 1\u20132). Prognostic performance was best at 24 hours for both MR-proANP and NT-proBNP; with an AUC of 0.73 (confidence interval [95% CI]: 0.63\u20130.83) and 0.72 (95 % CI: 0.59\u20130.85), respectively. Prolonged TTM lowered the levels of both MR-proANP and NT-proBNP at 48 hours. MR-proANP may add prognostic information in postcardiac arrest patients.\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    ID: NCT01689077\n                  <\/jats:p>","DOI":"10.1089\/ther.2021.0012","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T12:27:37Z","timestamp":1628598457000},"page":"82-89","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["MR-proANP and NT-proBNP During Targeted Temperature Management Following Out-of-Hospital Cardiac Arrest: A\n                    <i>Post hoc<\/i>\n                    Analysis of the TTH48 Trial"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3673-2575","authenticated-orcid":false,"given":"Henriette Michelsen","family":"Bach","sequence":"first","affiliation":[{"name":"Department of Intensive Care, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe Henri Valdemar","family":"Duez","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anni N\u00f8rgaard","family":"Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Regional Hospital West Jutland, Herning, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Strand","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Stavanger University Hospital, Stavanger, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldar","family":"S\u00f8reide","sequence":"additional","affiliation":[{"name":"Critical Care and Anesthesiology Research Group and Department of Clinical Medicine, Stavanager University Hospital, Stavanger, Norway."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Kirkegaard","sequence":"additional","affiliation":[{"name":"Research Center for Emergency Medicine, Emergency Department and Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders Morten","family":"Grejs","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_3_3_2_1","first-page":"428","article-title":"CT-proAVP (copeptin), MR-proANP and Peroxiredoxin 4 after cardiac arrest: release profiles and correlation to outcome. 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