{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:09:09Z","timestamp":1777939749760,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:p>\n                    Lung injury occurring in the early stage of heat stroke (HS) leads to hypoxia and further aggravation of other organic damage. Lactoferrin (LF) is an iron binding protein with anti-inflammatory and antioxidant effects. This study focuses on the protection of preadministration of bovine lactoferrin (BLF) against lung injury in rats with HS. Sixty-four Sprague-Dawley male rats were divided into four groups randomly: control (CON)+phosphate-buffered saline (PBS) (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200916), HS+PBS (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200916), HS+low-dose BLF (LBLF) (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200916), and HS+high-dose BLF (HBLF) (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200916). CON+PBS and HS+PBS were preadministered 10\u2009mL\/kg PBS for 1 week. HS+LBLF and HS+HBLF were preadministered 100 and 200\u2009mg\/kg BLF for 1 week, respectively. The HS onset time and the survival rate were recorded, and bronchoalveolar lavage fluid was obtained to measure protein concentration. Lung was obtained for pathological analysis and wet\/dry weight ratio measurement; later, the content of malondialdehyde (MDA), activity of myeloperoxidase (MPO), and superoxide dismutase (SOD) were measured in lung tissue homogenate. The results indicated that BLF preadministration could delay the HS onset time, enhance the survival rate, the levels of serum inflammatory cytokine and MDA content in HS+LBLF and HS+HBLF showed significant reduction compared with HS+PBS, while a significant elevation of SOD activity and reduction of MPO activity in HS+HBLF. Our results demonstrate that BLF preadministration could relieve lung injury in HS rats by enhancing thermal endurance, and alleviating serum inflammatory response and pulmonary oxidative stress damage.\n                  <\/jats:p>","DOI":"10.1089\/ther.2022.0002","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T14:21:45Z","timestamp":1653315705000},"page":"223-228","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Bovine Lactoferrin Alleviates Pulmonary Lipid Peroxidation and Inflammatory Damage in Heat Stroke Rats"],"prefix":"10.1177","volume":"12","author":[{"given":"Xinyu","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of Naval Medical University, Shanghai, China."},{"name":"Department of Emergency, The Third Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Vasculocardiology, The First People's Hospital of Kunshan, Suzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of Naval Medical University, Shanghai, China."},{"name":"Department of Emergency, The Second Naval Hospital of Southern Theater Command of PLA, Hainan, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaokang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Emergency, The Third Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"He","sequence":"additional","affiliation":[{"name":"Department of Emergency, The Third Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuogui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Trauma, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meitang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64074-1.00032-X"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144903"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31827a3618"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00433"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1556-276X-8-190"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1810762"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1585868"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00002"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.03.039"},{"key":"e_1_3_4_11_1","first-page":"9","article-title":"Effect of bovine lactoferrin as a novel therapeutic agent in a rat model of sepsis-induced acute lung injury","author":"Han N","year":"2019","unstructured":"Han N, , Li H, , Li G, et al. 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Preventive effects of Bacillus licheniformis on heat stroke in rats by sustaining intestinal barrier function and modulating gut microbiota. 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