{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:09:15Z","timestamp":1777939755319,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:p>Prognostic role of the amplitude-integrated electroencephalography (aEEG) is undeniable, but few works focused on the contribution of medications in misleading its interpretation. We report the case of an asphyxiated newborn enrolled for therapeutic hypothermia (TH) that required the simultaneous use of three anticonvulsants, whose administration resulted in a comatose state and in a switch to a flat trace on the aEEG. The prolonged flat trace on the aEEG, pointing toward a state of irreversible brain damage, led to early stop of TH to prevent therapeutic obstinacy; unexpectedly, once Midazolam was weaned off, the aEEG recovered to a discontinuous pattern. The case emphasizes the aEEG's noninfallibility and advises clinicians to consider the potential misleading effects of depressant medications on its interpretation in asphyxiated newborns undergoing TH.<\/jats:p>","DOI":"10.1089\/ther.2022.0028","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T11:46:42Z","timestamp":1666352802000},"page":"240-244","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Prolonged Background Suppression Induced by Anticonvulsants Misleading Amplitude-Integrated Electroencephalography's Interpretation: A Single Case Report"],"prefix":"10.1177","volume":"12","author":[{"given":"Raffaele","family":"Falsaperla","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, A.O. Policlinico G. Rodolico\u2013San Marco, Catania, Italy."},{"name":"Unit of Pediatrics, Neonatology and Neonatal Intensive Care, and Pediatric Emergency, AOU \u201cPoliclinico,\u201d PO \u201cSan Marco\u201d, University of Catania, Catania, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-1321","authenticated-orcid":false,"given":"Bruna","family":"Scalia","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, A.O. Policlinico G. Rodolico\u2013San Marco, Catania, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele A.","family":"Liotta","sequence":"additional","affiliation":[{"name":"Postgraduate Programme in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Cimino","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, A.O. Policlinico G. Rodolico\u2013San Marco, Catania, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martino","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Unit of Rare Diseases of the Nervous System, Section of Pediatrics and Child Neuropsychiatry, A.U.O. 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