{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:09:37Z","timestamp":1783955377930,"version":"3.55.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:p>\n                    Hypothermia affects coagulation, but the effect of hypothermia on fibrinolysis is not clarified. Imbalance in the fibrinolytic system may lead to increased risk of bleeding or thrombosis. Our aim was to investigate if resuscitated cardiac arrest patients treated with hypothermia had an unbalanced fibrinolysis. A prospective cohort study, including 82 patients were treated with hypothermia at 33\u00b0C\u2009\u00b1\u20091\u00b0C after out-of-hospital cardiac arrest. Blood samples were collected at 24 hours (hypothermia) and at 72 hours (normothermia). Samples were analyzed for fibrin D-dimer, tissue plasminogen activator (tPA), plasminogen, plasminogen activator Inhibitor-1 (PAI-1), thrombin-activatable fibrinolysis inhibitor (TAFI), and an in-house dynamic fibrin clot formation and lysis\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/assay.Compared\">assay.Compared<\/jats:ext-link>\n                    with normothermia, hypothermia significantly increased plasminogen activity (mean difference\u2009=\u200910.4%, 95% confidence interval [CI] 7.9\u201312.9),\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), PAI-1 levels (mean difference\u2009=\u2009275\u2009ng\/mL, 95% CI 203\u2013348,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and tPA levels (mean difference\u2009=\u20091.0\u2009ng\/mL, 95% CI 0.2\u20131.7,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.01). No differences between hypothermia and normothermia were found in TAFI activity (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.59) or in the fibrin D-dimer levels (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.08). The fibrin clot lysis curves showed three different patterns: normal-, flat-, or resistant clot lysis curve. At hypothermia 45 (55%) patients had a resistant clot lysis curve and 33 (44%) patients had a resistant clot lysis curve at normothermia (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.047). Comatose, resuscitated, cardiac arrest patients treated with hypothermia express an inhibited fibrinolysis even after rewarming. This could potentially increase the thromboembolic risk.\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    ID: NCT02258360.\n                  <\/jats:p>","DOI":"10.1089\/ther.2022.0037","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T17:08:17Z","timestamp":1670346497000},"page":"112-119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Fibrinolysis in Cardiac Arrest Patients Treated with Hypothermia"],"prefix":"10.1177","volume":"13","author":[{"given":"Anni N\u00f8rgaard","family":"Jeppesen","sequence":"first","affiliation":[{"name":"Anesthesia Section, Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Aarhus N, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Duez","sequence":"additional","affiliation":[{"name":"Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus N, Denmark."},{"name":"Department of Otolaryngology, Head and Neck Surgery, and Aarhus University Hospital, Aarhus N, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Kirkegaard","sequence":"additional","affiliation":[{"name":"Research Center for Emergency Medicine, Aarhus University Hospital, Aarhus N, Denmark."},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Morten","family":"Grejs","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark."},{"name":"Department of Intensive Care Medicine, Aarhus University Hospital, Aarhus N, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Mette","family":"Hvas","sequence":"additional","affiliation":[{"name":"Faculty of Health, Aarhus University, Aarhus C, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17172"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.09.003"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100591"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31817340ad"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000806"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1655953"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14480"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067476"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.08.040"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.02.007"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2017.06.004"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000062520.65192.C9"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-016-1338-9"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.8978"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22179540"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1725096"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezaa010"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.04.025"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3283423534"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.02.012"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.05.008"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.05.010"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199805000-00017"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2013.10.010"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000064328.97941.FC"}],"container-title":["Therapeutic 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