{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:13:53Z","timestamp":1781712833163,"version":"3.54.5"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:p>\n                    This study compared the pregnancy and neonatal outcomes between fresh embryo transfer and frozen-thawed embryo transfer (FET). These patients were split into two groups: the fresh embryo transfer group and the FET group. The general conditions, pregnancy outcomes, and neonatal outcomes between these groups were compared. The influencing factors of fetal macrosomia occurrence were explored as well. Compared with the fresh embryo transfer group, the FET group had a significantly higher mean age (32.59\u2009\u00b1\u20094.77 vs. 31.90\u2009\u00b1\u20094.71,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and lower multiple pregnancy rate (21.2% vs. 26.9%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). There was no significant difference in the incidence of congenital anomalies of neonates between the two groups (1.32% vs. 0.37%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05). In the FET group, compared with the fresh embryo transfer group, the mean birth weight of singleton live births, the cesarean section rate, and the incidence of fetal macrosomia were significantly increased, while the incidence of low birth weight was significantly decreased. The logistic analysis showed that the occurrence of fetal macrosomia was primarily associated with the embryo transfer protocol (odds ratio [OR]\u2009=\u20092.769, 95% confidence interval [CI]: 1.246\u20136.154,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05), endometrial thickness (OR\u2009=\u20091.144, 95% CI: 1.043\u20131.256,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05), and gestational age (OR\u2009=\u20091.710, 95% CI: 1.338\u20132.184,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Macrosomia (OR\u2009=\u20092.938, 95% CI: 1.436\u20136.010,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.003) and multiple pregnancy (OR\u2009=\u20093.574, 95% CI: 2.616\u20134.882,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001) significantly increased the cesarean section rate. The risk of fetal macrosomia and congenital anomalies in the offspring of the fresh embryo transfer group was lower than that in the offspring of the FET group, we preferred to fresh embryo transfer for patients with assisted reproductive technologies. FET should be used as supplementary therapeutic strategy with strengthened pregnancy management and screening to reduce the occurrence of birth defects in newborns.\n                  <\/jats:p>","DOI":"10.1089\/ther.2022.0045","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T10:33:50Z","timestamp":1679567630000},"page":"120-125","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Pregnancy and Neonatal Outcomes Between Fresh Embryo Transfer and Frozen\u2013Thawed Embryo Transfer"],"prefix":"10.1177","volume":"13","author":[{"given":"Man","family":"Chen","sequence":"first","affiliation":[{"name":"Reproductive Medicine Department, the First Affiliated Hospital of Shantou University Medical College, Shantou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-ling","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department, the First Affiliated Hospital of Shantou University Medical College, Shantou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Lin","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department, the First Affiliated Hospital of Shantou University Medical College, Shantou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-bin","family":"Xia","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department, the First Affiliated Hospital of Shantou University Medical College, Shantou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5845-5943","authenticated-orcid":false,"given":"Yu-lian","family":"Wang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department, the First Affiliated Hospital of Shantou University Medical College, Shantou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"issue":"12","key":"e_1_3_4_2_1","first-page":"1214","article-title":"[A multicenter comparative study of obstetric outcomes in single pregnancy with freeze-thaw and fresh cycle embryo transfer]","volume":"32","author":"Bai LN","year":"2016","unstructured":"Bai LN, , Qu WY, , Xu P, et al. [A multicenter comparative study of obstetric outcomes in single pregnancy with freeze-thaw and fresh cycle embryo transfer]. Chin J Pract Gynecol Obst, 2016; 32(12):1214\u20131217.","journal-title":"Chin J Pract Gynecol Obst"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev339"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15606"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103076"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15526"},{"issue":"4","key":"e_1_3_4_7_1","first-page":"607","article-title":"The effect of vitrification on expression and histone marks of Igf2 and Oct4 in blastocysts cultured from two-cell mouse embryos","volume":"19","author":"Jahangiri M","year":"2018","unstructured":"Jahangiri M, , Shahhoseini M, , Movaghar B. The effect of vitrification on expression and histone marks of Igf2 and Oct4 in blastocysts cultured from two-cell mouse embryos. Cell J, 2018; 19(4):607\u2013613.","journal-title":"Cell J"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.12.005"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.223"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23689"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.04.010"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa272"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.09.015"},{"issue":"4","key":"e_1_3_4_14_1","first-page":"516","article-title":"Excessive fetal growth in frozen embryo transfer: False alarm or clinical concern?","volume":"24","author":"Somigliana E","year":"2018","unstructured":"Somigliana E, , Vanni VS, , Busnelli A, et al. Excessive fetal growth in frozen embryo transfer: False alarm or clinical concern?. Hum Reprod Update, 2018; 24(4):516\u2013517.","journal-title":"Hum Reprod Update"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2017.07.001"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew184"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex234"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.04.015"},{"issue":"01","key":"e_1_3_4_19_1","first-page":"9","article-title":"[Neonatal outcomes of freeze-thaw and fresh embryo transfer]","volume":"26","author":"Zhou J","year":"2017","unstructured":"Zhou J, , Li B, , Chen SQ, et al. [Neonatal outcomes of freeze-thaw and fresh embryo transfer]. Sheng Zhi Yi Xue Za Zhi, 2017; 26(01):9\u201313.","journal-title":"Sheng Zhi Yi Xue Za Zhi"}],"container-title":["Therapeutic Hypothermia and Temperature Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ther.2022.0045","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ther.2022.0045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ther.2022.0045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:27:22Z","timestamp":1777699642000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ther.2022.0045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,23]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9,1]]}},"alternative-id":["10.1089\/ther.2022.0045"],"URL":"https:\/\/doi.org\/10.1089\/ther.2022.0045","relation":{},"ISSN":["2153-7658","2153-7933"],"issn-type":[{"value":"2153-7658","type":"print"},{"value":"2153-7933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,23]]}}}