{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:09:16Z","timestamp":1777939756187,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:p>\n                    The Swiss National Asphyxia and Cooling Register was implemented in 2011. This study assessed quality indicators of the cooling process and (short-term) outcomes of neonates with hypoxic-ischemic encephalopathy (HIE) receiving therapeutic hypothermia (TH) longitudinally over time in Switzerland. This is a multicenter national retrospective cohort study of prospectively collected register data. Quality indicators were defined for longitudinal comparison (2011\u20132014 vs. 2015\u20132018) of processes of TH and (short-term) outcomes of neonates with moderate-to-severe HIE. Five hundred seventy neonates receiving TH in 10 Swiss cooling centers were included (2011\u20132018). Four hundred forty-nine (449\/570; 78.8%) neonates with moderate-to-severe HIE received TH according to the Swiss National Asphyxia and Cooling Register Protocol. Quality indicators of processes of TH improved in 2015\u20132018 (compared with 2011\u20132014): less passive cooling (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.013), shorter time to reach target temperature (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.002), and less over- or undercooling (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In 2015\u20132018, adherence to performing a cranial magnetic resonance imaging after rewarming improved (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), whereas less cranial ultrasounds were performed on admission (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.012). With regard to quality indicators of short-term outcomes, persistent pulmonary hypertension of the neonate was reduced (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.003), and there was a trend toward less coagulopathy (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.063) in 2015\u20132018. There was no statistically significant change in the remaining processes and outcomes. The Swiss National Asphyxia and Cooling Register is well implemented with good overall adherence to the treatment protocol. Management of TH improved longitudinally. Continuous reevaluation of register data is desirable for quality assessment, benchmarking, and maintaining international evidence-based quality standards.\n                  <\/jats:p>","DOI":"10.1089\/ther.2022.0055","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T10:08:51Z","timestamp":1677060531000},"page":"175-183","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Increase in Standardized Management of Neonates with Hypoxic-Ischemic Encephalopathy Since Implementation of a Patient Register"],"prefix":"10.1177","volume":"13","author":[{"given":"Andr\u00e9","family":"Birkenmaier","sequence":"first","affiliation":[{"name":"University of Zurich, Faculty of Medicine, Department of Neonatology and Pediatric Intensive Care, Children's Hospital St. Gallen, Neonatal and Pediatric Intensive Care Unit, St. Gallen, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Adams","sequence":"additional","affiliation":[{"name":"Newborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kleber","sequence":"additional","affiliation":[{"name":"Clinic of Neonatology, Cantonal Hospital Winterthur, Winterthur, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Schwendener Scholl","sequence":"additional","affiliation":[{"name":"Department of Neonatology and Pediatric Intensive Care, Children's Hospital, Lucerne, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Rathke","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Pediatric Intensive Care, University Children's Hospital Zurich, Zurich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Hagmann","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Pediatric Intensive Care, University Children's Hospital Zurich, Zurich, Switzerland."},{"name":"University of Zurich, Faculty of Medicine, Zurich, Switzerland."},{"name":"Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Brotschi","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Pediatric Intensive Care, University Children's Hospital Zurich, Zurich, Switzerland."},{"name":"University of Zurich, Faculty of Medicine, Zurich, Switzerland."},{"name":"Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4965-2814","authenticated-orcid":false,"given":"Beate","family":"Grass","sequence":"additional","affiliation":[{"name":"Newborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland."},{"name":"Division of Neonatology and Pediatric Intensive Care, University Children's Hospital Zurich, Zurich, Switzerland."},{"name":"University of Zurich, Faculty of Medicine, Zurich, Switzerland."},{"name":"Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Swiss National Asphyxia and Cooling Register","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-01156-w"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02688-y"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315788"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900854"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.07.003"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-022-01412-7"},{"issue":"11","key":"e_1_3_6_8_1","first-page":"SC16","article-title":"To study the correlation of Thompson scoring in predicting early neonatal outcome in post asphyxiated term neonates","volume":"10","author":"Bhagwani DK","year":"2016","unstructured":"Bhagwani DK, , Sharma M, , Dolker S, et al. 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