{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:56:04Z","timestamp":1783612564910,"version":"3.55.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"\n Cerebral tissue oxygen saturation (CrSO\n 2<\/jats:sub>\n ) measured with near-infrared spectroscopy (NIRS) technology has recently become the subject of several research studies. The aim of this study was to investigate the diagnostic value of CrSO\n 2<\/jats:sub>\n measurements in perinatal asphyxia (PA) cases. The study included a patient group of 42 PA cases, who were to be applied with therapeutic hypothermia (TH), and a control group of 42 healthy term newborns. PA cases were determined as moderate or severe encephalopathy (Sarnat score stage II or III) in clinical evaluation. In both groups, left (CrSO\n 2<\/jats:sub>\n L) and right (CrSO\n 2<\/jats:sub>\n R) NIRS measurements were taken for 10 minutes on the scalp. The arithmetic mean value of measurements was calculated and compared. The mean measurements were CrSO\n 2<\/jats:sub>\n R 67.38\u2009\u00b1\u20099.39 and CrSO\n 2<\/jats:sub>\n L 66.73\u2009\u00b1\u20097.76 in the patient group, and CrSO\n 2<\/jats:sub>\n R 80.28\u2009\u00b1\u20098.04 and CrSO\n 2<\/jats:sub>\n L 79.14\u2009\u00b1\u20098.49 in the control group. The mean CrSO\n 2<\/jats:sub>\n R and CrSO\n 2<\/jats:sub>\n L measurements of the patient group were statistically significantly lower than those of the control group (\n p<\/jats:italic>\n \u2009<\u20090.001). In the Pearson correlation analysis, a significant correlation was determined in the patient group between cord blood gas pH and CrSO\n 2<\/jats:sub>\n R (\n r<\/jats:italic>\n : 0.539,\n p<\/jats:italic>\n \u2009<\u20090.001) and CrSO\n 2<\/jats:sub>\n L (\n r<\/jats:italic>\n : 0.54,\n p<\/jats:italic>\n \u2009<\u20090.001). For a cutoff value of CrSO\n 2<\/jats:sub>\n L\u2009\u2264\u200972%, the positive predictive value was 80 and the negative predictive value was 84.6. For a cutoff value of CrSO\n 2<\/jats:sub>\n R\u2009\u2264\u200974%, the positive predictive value was 79.5 and the negative predictive value was 82.5. Low CrSO\n 2<\/jats:sub>\n measurements obtained with the NIRS method in PA cases to be applied with TH together with cord blood gas parameters can be considered a helpful parameter in diagnosis.\n <\/jats:p>","DOI":"10.1089\/ther.2022.0060","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T10:13:32Z","timestamp":1678875212000},"page":"184-190","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cerebral Tissue Oxygen Saturation Measurements in Perinatal Asphyxia Cases Treated with Therapeutic Hypothermia"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4671-4028","authenticated-orcid":false,"given":"Halil","family":"Kazanasmaz","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-9404","authenticated-orcid":false,"given":"Abdulsamed","family":"Akan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7406-4950","authenticated-orcid":false,"given":"\u00d6mer","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-5030","authenticated-orcid":false,"given":"Muhammed Turgut","family":"\u00d6l\u00e7\u00fcc\u00fc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3687-3335","authenticated-orcid":false,"given":"Selehattin","family":"Onar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harran University Faculty of Medicine, Sanliurfa, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-5559","authenticated-orcid":false,"given":"\u00d6zlem","family":"Kazanasmaz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Sanliurfa, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2012.09.006"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-019-00291-2"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/ther.2017.0024"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73453-x"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.15409"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2011.0028"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2021-006135"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13983"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2021.01.014"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-016-2266-0"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201903-0583OC"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2017.012"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2017.07.008"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1297790"},{"issue":"3","key":"e_1_3_4_16_1","first-page":"364","article-title":"C-reactive protein and blood gas analysis in cases of neonatal encephalopathy treated with therapeutic hypothermia","volume":"50","author":"Kazanasmaz H","year":"2020","unstructured":"Kazanasmaz H, , Gumus H. C-reactive protein and blood gas analysis in cases of neonatal encephalopathy treated with therapeutic hypothermia. Ann Clin Lab Sci, 2020; 50(3):364\u2013370.","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13049-015-0173-4"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.03.051"},{"key":"e_1_3_4_19_1","first-page":"50","article-title":"Hypothermia in neonatal hypoxic-ischemic encephalopathy (HIE)","volume":"21","author":"Liu G","year":"2017","unstructured":"Liu G, , Li ZG, , Gao JS. Hypothermia in neonatal hypoxic-ischemic encephalopathy (HIE). 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