{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:09:18Z","timestamp":1777939758315,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:p>\n                    Targeted temperature management (TTM) may moderate the injury from out-of-hospital cardiac arrest. Slowing the metabolism has been a suggested effect. Nevertheless, studies have found higher lactate levels in patients cooled to 33\u00b0C compared with 36\u00b0C even days from TTM cessation. Larger studies have not been performed on the TTM's effect on the metabolome. Accordingly, to explore the effect of TTM, we used ultra-performance liquid\u2013mass spectrometry in a substudy of 146 patients randomized in the TTM trial to either 33\u00b0C or 36\u00b0C for 24 hours and quantified 60 circulating metabolites at the time of hospital arrival (T\n                    <jats:sub>0<\/jats:sub>\n                    ) and 48 hours later (T\n                    <jats:sub>48<\/jats:sub>\n                    ). From T\n                    <jats:sub>0<\/jats:sub>\n                    to T\n                    <jats:sub>48,<\/jats:sub>\n                    profound changes to the metabolome were observed: tricarboxylic acid (TCA) cycle metabolites, amino acids, uric acid, and carnitine species all decreased. TTM significantly modified these changes in nine metabolites (Benjamini\u2013Hochberg corrected false discovery rate &lt;0.05): branched amino acids valine and leucine levels dropped more in the 33\u00b0C arm (change [95% confidence interval]: \u221260.9\u2009\u03bcM [\u221270.8 to \u221250.9] vs. \u221236.0\u2009\u03bcM [\u221245.8 to \u221226.3] and \u221235.5\u2009\u03bcM [\u221243.1 to \u221227.8] vs. \u221221.2\u2009\u03bcM [\u221228.7 to \u221213.6], respectively), whereas the TCA metabolites including malic acid and 2-oxoglutaric acid remained higher for the first 48 hours (\u22127.7\u2009\u03bcM [\u22129.7 to \u22125.7] vs. \u221210.4\u2009\u03bcM [\u221212.4 to \u22128.4] and \u22123\u2009\u03bcM [\u22124.3 to \u22121.7] vs. \u22123.7\u2009\u03bcM [\u22125 to \u22122.3]). Prostaglandin E2 only dropped in the TTM 36\u00b0C group. The results show that TTM affects the metabolism hours after normothermia have been reached.\n                  <\/jats:p>\n                  <jats:p>Clinical Trial Number: NCT01020916<\/jats:p>","DOI":"10.1089\/ther.2022.0065","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T12:25:12Z","timestamp":1684844712000},"page":"208-215","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Effect of Targeted Temperature Management on the Metabolome Following Out-of-Hospital Cardiac Arrest"],"prefix":"10.1177","volume":"13","author":[{"given":"Rasmus Paulin","family":"Beske","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital\u2013Rigshospitalet, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laust Emil Roelsgaard","family":"Obling","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital\u2013Rigshospitalet, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bro-Jeppesen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences at Helsingborg, Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Abild Steengaard","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital\u2013Rigshospitalet, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Kjaergaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital\u2013Rigshospitalet, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4r Ingemar","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Center for Endotheliomics, CAG, Copenhagen University Hospital\u2013Rigshospitalet, Copenhagen, Denmark."},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Hassager","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Centre, Copenhagen University Hospital\u2013Rigshospitalet, Copenhagen, Denmark."},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3375-8"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.08.006"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000691"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.001556"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114858"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100591"},{"key":"e_1_3_5_8_1","first-page":"1","article-title":"UPLC\/MS monitoring of water-soluble vitamin Bs in cell culture media in minutes","author":"Doneanu CE","year":"2011","unstructured":"Doneanu CE, , Chen W, , Mazzeo JR, et al. UPLC\/MS monitoring of water-soluble vitamin Bs in cell culture media in minutes. Waters Appl Notes, 2011; 1\u20137.","journal-title":"Waters Appl Notes"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.10.005"},{"key":"e_1_3_5_10_1","first-page":"4","article-title":"Targeted temperature management following out-of-hospital cardiac arrest: A systematic review and network meta-analysis of temperature targets","volume":"47","author":"Fernando SM","year":"2021","unstructured":"Fernando SM, , Santo PD, , Sadeghirad B, et al. Targeted temperature management following out-of-hospital cardiac arrest: A systematic review and network meta-analysis of temperature targets. 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