{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:09:19Z","timestamp":1777939759789,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:p>\n                    The aim of this study was to describe whether whole-body hypothermia induced different respiratory changes in both invasively and noninvasively ventilated newborns and spontaneously breathing asphyxiated newborns during the course and after therapeutic hypothermia (TH). Data of 44 asphyxiated newborns undergoing TH at five different neonatal intensive care units in southern Italy were collected retrospectively between January 2018 and January 2021. For each type of ventilation, patient data on pH, partial pressure of Carbon Dioxide (pCO\n                    <jats:sub>2<\/jats:sub>\n                    ), base excess, lactate, and heart rate were recorded before cooling was started and at 24, 48, 72, and 96 hours from its initiation. Patients were later subgrouped into spontaneously breathing, noninvasively ventilated, and mechanically ventilated groups. The average trend of each parameter was reported, and a nonparametric statistical analysis of differences among groups before initiation and at 96 hours was performed using the Kruskal\u2013Wallis test. Our results confirmed previous findings (supported by a small amount of literature) that no increase in requests for respiratory support is recorded in asphyxiated newborns undergoing TH during and after the rewarming phase. Furthermore, no statistically significant differences in the analyzed parameters were found among spontaneously breathing, noninvasively ventilated, and mechanically ventilated newborns, suggesting that changes in parameters might be attributable to TH itself rather than to an improvement in the respiratory condition over time; otherwise, a difference between spontaneously breathing patients, by definition \u201cstable\u201d from a respiratory point of view, and those requiring any type of respiratory support would have been expected.\n                  <\/jats:p>","DOI":"10.1089\/ther.2022.0066","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T11:48:53Z","timestamp":1684151333000},"page":"200-207","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Respiratory Changes in Ventilated and Not-Ventilated Neonates During and After Whole-Body Hypothermia: A Multicenter Retrospective Study"],"prefix":"10.1177","volume":"13","author":[{"given":"Raffaele","family":"Falsaperla","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, A.O.U. Policlinico G. Rodolico\u2014San Marco, Catania, Italy."},{"name":"Pediatric and Pediatric Emergency Department, University Hospital \u201cPoliclinico San Marco,\u201d Catania, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-1321","authenticated-orcid":false,"given":"Bruna","family":"Scalia","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, A.O.U. Policlinico G. Rodolico\u2014San Marco, Catania, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Costanza","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pediatrics, Department of Clinical and Experimental Medicine, Pediatric Postgraduate Training Program, University of Catania, Catania, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Termini","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Hospital \u201cVilla Sofia Cervello,\u201d Palermo, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"De Vivo","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Monaldi Hospital, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Cacace","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Barone Romeo Hospital, Patti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Mondello","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Hospital \u201cBianchi-Melacrino-Morelli,\u201d Reggio Calabria, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martino","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pediatrics, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Catania, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.09.006"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2016.11.001"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198711000-00001"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12476"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.25.1.105"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2021.101263"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-021-01027-2"},{"key":"e_1_3_4_9_1","volume-title":"Guyton and Hall Textbook of Medical Physiology","author":"Hall J.","year":"2011","unstructured":"Hall J. Guyton and Hall Textbook of Medical Physiology, 12th ed. Saunders Elsevier: Philadelphia, PA; 2011.","edition":"12"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.7-2-e76"},{"key":"e_1_3_4_11_1","unstructured":"Italian Society of Neonatology. Raccomandazioni per l'assistenza al neonato con encefalopatia ipossico-ischemica candidato al trattamento ipotermico. Gruppo di Studio di Neurologia Neonatale. A cura di Gina Ancora Giulia Pomero Fabrizio Ferrari. 2012. Available from: https:\/\/www.sin-neonatologia.it\/raccomandazioni-per-lassistenza-al-neonato-con-encefalopatia-ipossicoischemica-possibile-candidato-al-trattamento-ipotermico. Accessed February13 2023."},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/79.6.726"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2018.10.001"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181aa5241"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/1053-0770(94)90195-3"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1694730"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0349-2"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-0916-0"}],"container-title":["Therapeutic Hypothermia and Temperature Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ther.2022.0066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ther.2022.0066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ther.2022.0066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:27:30Z","timestamp":1777699650000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ther.2022.0066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,30]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12,1]]}},"alternative-id":["10.1089\/ther.2022.0066"],"URL":"https:\/\/doi.org\/10.1089\/ther.2022.0066","relation":{},"ISSN":["2153-7658","2153-7933"],"issn-type":[{"value":"2153-7658","type":"print"},{"value":"2153-7933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,30]]}}}