{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:37:50Z","timestamp":1790699870721,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>\n                    To assess the effectiveness and molecular mechanisms of mild hypothermia and remote ischemic postconditioning (RIPC) in patients with acute ischemic stroke (AIS) who have undergone thrombolysis therapy. A total of 58 AIS patients who received recombinant tissue plasmin activator (rt-PA) intravenous thrombolysis were included in this prospective study. Participants were randomly allocated to the experimental group (rt-PA intravenous thrombolysis plus mild hypothermic ice cap plus remote ischemic brain protection,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200930) and the control group (rt-PA intravenous thrombolysis plus 0.9% saline,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200928). The RIPC was performed for 14 consecutive days on both upper limb arteries spaced 2 minutes apart. Five cycles of ischemia\u2013reperfusion were performed sequentially (2\u20132, 3\u20133, 4\u20134, 5\u20135, 5\u20130 minutes, respectively). The outcome measures of the National Institute of Health stroke scale (NIHSS) score, volume of cerebral infarction, serum levels of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-1\u03b2, tumor necrosis factor \u03b1, nuclear factors kappa B (NF-\u03baB), and NOD-1ike receptor pyrin 3 (NLRP3) were evaluated at different time points after treatment. Similarly, the 90-day modified Rankin Scale (mRS) scores were compared between the two groups. After treatment, the NIHSS score, MDA, NF-\u03baB, and NLRP3 levels in the experimental group were significantly lower than those in the control group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05). While the SOD in the experimental group was significantly higher than in the control group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05), the NIHSS scores decreased within groups (all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) in both experimental and control groups. The 90-day mRS score (0\u20132 points) in the experimental group was significantly higher than that in the control group (73.33% vs. 53.57%,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and no significant differences were observed in the safety indices between the two groups (all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05). Our study shows that combining mild hypothermia and RIPC has a positive effect on brain protection and can significantly reduce the oxidative stress and associated outburst of inflammatory response. The Clinical Trial Registration number is ChiCTR2300073136.\n                  <\/jats:p>","DOI":"10.1089\/ther.2023.0043","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T11:08:51Z","timestamp":1693912131000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Brain Protection Effects of Mild Hypothermia Combined with Distant Ischemic Postconditioning and Thrombolysis in Patients with Acute Ischemic Stroke"],"prefix":"10.1177","volume":"14","author":[{"given":"Changping","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Heilongjiang Provincial Hospital, Harbin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Qingdao Huangdao District Central Hospital, Qingdao, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Prevention and Control, Qingdao West Coast New Area Disease Prevention and Control Center, Qingdao, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfeng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Hospital of Harbin, Harbin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Heilongjiang Provincial Hospital, Harbin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jujun","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology, Heilongjiang Provincial Hospital, Harbin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology, Heilongjiang Provincial Hospital, Harbin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengli","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology, Heilongjiang Provincial Hospital, Harbin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianrong","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Heilongjiang Provincial Hospital, Harbin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Geriatric Neurology, Heilongjiang Provincial Hospital, Harbin, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1987.127"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.326"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00155"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-015-0444-4"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.223"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14440"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-012233"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.08.025"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx133"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2015-0043"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-021-00852-0"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S231944"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2534"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017283"},{"issue":"4","key":"e_1_3_4_16_1","first-page":"289","article-title":"[Interpretation of 2018 guidelines for the early management of patients with acute ischemic stroke]","volume":"30","author":"Wang G","year":"2018","unstructured":"Wang G, , Fang B, , Yu X, et al. [Interpretation of 2018 guidelines for the early management of patients with acute ischemic stroke]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 2018; 30(4):289\u2013295; doi: 10.3760\/cma.j.issn.2095-4352.2018.04.001","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-016-0360-5"},{"issue":"03","key":"e_1_3_4_18_1","first-page":"250","article-title":"Neuroprotective effect of remote ischemic conditioning on cognitive impairment due to cerebral ischemia-reperfusion injury in rats","volume":"15","author":"Xu YM","year":"2020","unstructured":"Xu YM, , Zhou WJ, , Shan H, et al. Neuroprotective effect of remote ischemic conditioning on cognitive impairment due to cerebral ischemia-reperfusion injury in rats. Chin J Stroke, 2020; 15(03):250\u2013256; doi: 10.3969\/j.issn.1673-5765.2020.03.005","journal-title":"Chin J Stroke"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3174"},{"issue":"7","key":"e_1_3_4_20_1","first-page":"Cd012503","article-title":"Remote ischaemic conditioning for preventing and treating ischaemic stroke","volume":"7","author":"Zhao W","year":"2018","unstructured":"Zhao W, , Zhang J, , Sadowsky MG, et al. Remote ischaemic conditioning for preventing and treating ischaemic stroke. 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