{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:18:33Z","timestamp":1788506313087,"version":"build-2803163510"},"reference-count":14,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>\n                    We aimed to compare serum thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels in neonates with different hypoxic\u2013ischemic encephalopathy (HIE) stages undergoing therapeutic hypothermia (TH), and to evaluate the TSH and fT4 levels in neonates with HIE\/TH in comparison with a control group. This was a retrospective study conducted between January 2020 and December 2022. The neonates with HIE\/TH constituted the study group and the neonates with transient tachypnea of the newborn (TTN) constituted the control group. The study group consisted of neonates with stage 2 and stage 3 HIE. Serum TSH and fT4 levels measured at postnatal fifth day were compared between the groups. Of the 202 (47.1%) neonates included in the study group, 144 (71.3%) had stage 2 HIE and 58 (28.7%) had stage 3 HIE. In the control group, there were 227 (52.9%) newborns. Serum TSH and fT4 levels were found to be lower in the newborns with stage 3 HIE compared with those with stage 2 HIE (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.015, 0.002, respectively). Although the serum TSH level was higher in the newborns with HIE compared with the newborns with TTN, serum fT4 levels did not change between the groups (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u2009&lt; 0.001, 0.14, respectively). When we made the analysis according to the reference intervals, HIE\/TH was associated with higher rates of TSH elevation compared with TTN, and the difference was more pronounced in stage 2 HIE\/TH (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Although stage 3 HIE\/TH was significantly associated with higher rates of low fT4 compared with TTN (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.006), this relationship was not significant between stage 2 HIE\/TH and TTN. It would be reasonable to interpret thyroid function tests performed on the fifth day with caution in newborns with HIE\/TH, because higher TSH and lower fT4 levels on the fifth day in this patient group may result in unnecessary repetition of tests.\n                  <\/jats:p>","DOI":"10.1089\/ther.2023.0046","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T17:01:18Z","timestamp":1694538078000},"page":"186-190","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Association Between Hypoxic\u2013Ischemic Encephalopathy and Thyroid Hormones"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-0648","authenticated-orcid":false,"given":"Asli","family":"Okbay Gunes","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aydin","family":"Bozkaya","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"issue":"1","key":"e_1_3_3_2_1","first-page":"S32","article-title":"Turkish Neonatal Society Guideline on neonatal encephalopathy","volume":"53","author":"Akisu M","year":"2018","unstructured":"Akisu M, , Kumral A, , Canpolat FE. Turkish Neonatal Society Guideline on neonatal encephalopathy. Turk Pediatri Ars, 2018; 53(Suppl 1):S32\u2013S44; doi: 10.5152\/TurkPediatriArs.2018.01805","journal-title":"Turk Pediatri Ars"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-020-0757-3"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-0899"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80031-7"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(00)00253-0"},{"key":"e_1_3_3_7_1","first-page":"CD003311","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","author":"Jacobs SE","year":"2013","unstructured":"Jacobs SE, , Berg M, , Hunt R, et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev, 2013; CD003311.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13534"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.05.010"},{"issue":"1","key":"e_1_3_3_10_1","first-page":"S209","article-title":"Neonatal effects of thyroid diseases in pregnancy and approach to the infant with increased TSH: Turkish Neonatal and Pediatric Endocrinology and Diabetes Societies consensus report","volume":"53","author":"\u00d6zon A","year":"2018","unstructured":"\u00d6zon A, , Tekin N, , \u015e\u0131klar Z, et al. Neonatal effects of thyroid diseases in pregnancy and approach to the infant with increased TSH: Turkish Neonatal and Pediatric Endocrinology and Diabetes Societies consensus report. Turk Pediatri Ars, 2018; 53(Suppl 1):S209\u2013S223; doi: 10.5152\/TurkPediatriArs.2018.01819","journal-title":"Turk Pediatri Ars"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb00556.x"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.2000.01275.x"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.1994.7.1.39"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0333"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/ther.2022.0001"}],"container-title":["Therapeutic Hypothermia and Temperature Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ther.2023.0046","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ther.2023.0046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ther.2023.0046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:27:50Z","timestamp":1777699670000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ther.2023.0046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9,1]]}},"alternative-id":["10.1089\/ther.2023.0046"],"URL":"https:\/\/doi.org\/10.1089\/ther.2023.0046","relation":{},"ISSN":["2153-7658","2153-7933"],"issn-type":[{"value":"2153-7658","type":"print"},{"value":"2153-7933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,1]]}}}