{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:09:28Z","timestamp":1777939768990,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>\n                    This study aimed to explore the antipyretic and anti-inflammatory effects of rectal administration of Reduning injection in feverish rats induced by lipopolysaccharide (LPS), and observe the temperature changes and inflammatory indexes. The selected rats were randomly divided into 6 groups, with 10 rats in each group, named as normal empty group, model group, intravenous group (2\u2009mL\/kg), low-dose enema group (1\u2009mL\/kg), middle-dose enema group (2\u2009mL\/kg), and high-dose enema group (4\u2009mL\/kg). The hourly temperature variations in rats injected with LPS in the abdomen were recorded. Five hours later, blood samples from the abdominal aorta were collected to monitor immunoglobulin M (IgM), immunoglobulin A (IgA), interleukin (IL)-6, and tumor necrosis factor (TNF)-\u03b1. At 5 hours, the fever peak induced by LPS appeared, and obvious antipyretic effects were observed; the effect was optimal in the medium dose enema group at 4 hours (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.05); the IgM value in the enema groups, the intravenous group, and normal empty group was significantly lower than that in the model group; the IgA value in each group was higher than that in the model group, but there was no statistical significance (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05); values of IL-6 and TNF-\u03b1 in each group were lower than those in the model group, and the difference was statistically significant except for the high-dose enema group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&gt;\u20090.05). Low-dose and medium-dose rectal administration of Reduning injection have inhibitory effects on IL-6, TNF-\u03b1, and IgM in feverish rats induced by LPS, but there is no obvious difference compared to intravenous administration and it could achieve an anti-inflammatory effect. There is a possibility of enhancing IgA immunity with rectal administration, but there is no obvious difference compared to intravenous administration, and rectal administration has no significant effect on mucosal immunity.\n                  <\/jats:p>","DOI":"10.1089\/ther.2023.0056","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T16:55:11Z","timestamp":1697648111000},"page":"191-196","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Antipyretic and Anti-Inflammatory Effects of Rectal Administration of Reduning Injection in Feverish Rats Induced by Lipopolysaccharide"],"prefix":"10.1177","volume":"14","author":[{"given":"Miao-Yuan","family":"Li","sequence":"first","affiliation":[{"name":"First school of Clinical Medicine of Nanjing University of Chinese Medicine, Nanjing, China."},{"name":"Department of Traditional Chinese Medicine, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China."},{"name":"Department of Traditional Chinese Medicine, Affiliated Maternity Hospital and Affiliated Children's Hospital of Guangxi University of Science and Technology, Liuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin-Yuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China."},{"name":"Department of Traditional Chinese Medicine, Affiliated Maternity Hospital and Affiliated Children's Hospital of Guangxi University of Science and Technology, Liuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China."},{"name":"Department of Traditional Chinese Medicine, Affiliated Maternity Hospital and Affiliated Children's Hospital of Guangxi University of Science and Technology, Liuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun-Quan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China."},{"name":"Department of Traditional Chinese Medicine, Affiliated Maternity Hospital and Affiliated Children's Hospital of Guangxi University of Science and Technology, Liuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huo-Qing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China."},{"name":"Department of Traditional Chinese Medicine, Affiliated Maternity Hospital and Affiliated Children's Hospital of Guangxi University of Science and Technology, Liuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, China."},{"name":"Department of Traditional Chinese Medicine, Affiliated Maternity Hospital and Affiliated Children's Hospital of Guangxi University of Science and Technology, Liuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xiong","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"issue":"11","key":"e_1_3_3_2_1","first-page":"125","article-title":"Molecular and in silico evidences explain the anti-inflammatory effect of Trachyspermum ammi essential oil in lipopolysaccharide induced macrophages","volume":"96","author":"Bahuguna A","year":"2020","unstructured":"Bahuguna A, , Ramalingam S, , Arumugam A, et al. Molecular and in silico evidences explain the anti-inflammatory effect of Trachyspermum ammi essential oil in lipopolysaccharide induced macrophages. Proc Biochem, 2020; 96(11):125\u2013127.","journal-title":"Proc Biochem"},{"issue":"9","key":"e_1_3_3_3_1","first-page":"26","article-title":"Analysis on related factors of reports of adverse drug reaction induced by reduning injection in 73 children's with bronchopneumonia","volume":"11","author":"Cao Z","year":"2019","unstructured":"Cao Z, , Shi XK, , Zhang J, et al. Analysis on related factors of reports of adverse drug reaction induced by reduning injection in 73 children's with bronchopneumonia. Anti Infect Pharm, 2019; 11(9):26\u201327.","journal-title":"Anti Infect Pharm"},{"issue":"9","key":"e_1_3_3_4_1","first-page":"2097","article-title":"Effect of Reduning Injection on Vero cells and suckling mice infected by EV71 virus and its mechanism","volume":"49","author":"Chang XJ","year":"2018","unstructured":"Chang XJ, , Sun XP, , Hu HF, et al. Effect of Reduning Injection on Vero cells and suckling mice infected by EV71 virus and its mechanism. Chin Tradition Herb Drugs, 2018; 49(9):2097\u20132102.","journal-title":"Chin Tradition Herb Drugs"},{"issue":"02","key":"e_1_3_3_5_1","first-page":"236","article-title":"Mechanism of Reduning Injection on anti-acute lung injury in rats based on cytokine storm","volume":"46","author":"Chang XJ","year":"2015","unstructured":"Chang XJ, , Zhang S, , Jiang YP, et al. Mechanism of Reduning Injection on anti-acute lung injury in rats based on cytokine storm. Chin Tradition Herb Drugs, 2015; 46(02):236\u2013239.","journal-title":"Chin Tradition Herb Drugs"},{"issue":"17","key":"e_1_3_3_6_1","first-page":"33","article-title":"The protective effect of lidocaine on lipopolysaccharide-induced acute lung injury in rats through NF-\u03baB and p38 MAPK signaling pathway and excessive inflammatory responses","volume":"25","author":"Chen LJ","year":"2018","unstructured":"Chen LJ, , Ding YB, , Ma PL, et al. The protective effect of lidocaine on lipopolysaccharide-induced acute lung injury in rats through NF-\u03baB and p38 MAPK signaling pathway and excessive inflammatory responses. 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Identification of metabolites of Reduning injection in rat plasma, bile, urine and feces after intravenous administration. Acta Pharm Sin, 2018; 6(17):63\u201365.","journal-title":"Acta Pharm Sin"},{"issue":"23","key":"e_1_3_3_16_1","first-page":"96","article-title":"New rectal drug delivery system and clinical application progress","volume":"35","author":"Wang JH","year":"2019","unstructured":"Wang JH, , Liu M, , Du XF, et al. New rectal drug delivery system and clinical application progress. Gansu Sci Technol, 2019; 35(23):96\u201398\u2009+\u200995.","journal-title":"Gansu Sci Technol"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173563"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113783"},{"issue":"8","key":"e_1_3_3_19_1","first-page":"1026","article-title":"Progress in enema treatment of external fever in children","volume":"20","author":"Wei L","year":"2011","unstructured":"Wei L. 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