{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:09:28Z","timestamp":1777939768544,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2024,12,1]]},"abstract":"<jats:p>\n                    Cancer treatment often involves excisional surgery, but this approach may leave behind minimal residual disease, leading to tumor regrowth. Proinflammatory cytokines and their role in altering residual cancerous cells postsurgery have garnered attention. The study examines how mild intraoperative cooling affects cancer cells and their gene expression. It aims to discover strategies for reducing tumor growth after surgery. Nine cases of solid tumor were included in the study, nine samples were cooled with the Peltier\u2013Seebeck device down to12\u00b0C, and cooled and noncooled regions of tumors were analyzed using reverse transcription-polymerase chain reaction. Key transcriptomes, including neural-cadherin, cadherins (\n                    <jats:italic toggle=\"yes\">CDH<\/jats:italic>\n                    ), 70-kDa Heat Shock Protein (\n                    <jats:italic toggle=\"yes\">HSP70<\/jats:italic>\n                    ), hypoxia-inducible factor (\n                    <jats:italic toggle=\"yes\">HIF<\/jats:italic>\n                    ), Y-Box-binding protein 1 (\n                    <jats:italic toggle=\"yes\">YB-1<\/jats:italic>\n                    ), matrix metalloproteinase 9 (\n                    <jats:italic toggle=\"yes\">MMP9<\/jats:italic>\n                    ), and matrix metalloproteinase 2 (\n                    <jats:italic toggle=\"yes\">MMP2<\/jats:italic>\n                    ), were measured to assess the impact of mild hypothermia on cancer cell metabolism and cold shock responses. Analysis of cooled and noncooled regions revealed reduced MMP2\/9 levels in cooled regions in five out of seven cases, indicating potential suppression of tumor invasion and metastasis.\n                    <jats:italic toggle=\"yes\">CDH-1<\/jats:italic>\n                    expression was detected in five cases, with decreased levels observed in cooled regions in most cases, suggesting a role in tumor aggressiveness.\n                    <jats:italic toggle=\"yes\">YB-1<\/jats:italic>\n                    expression was increased in six out of eight samples, possibly correlating with local recurrence and reduced overall survival times.\n                    <jats:italic toggle=\"yes\">N-Cad<\/jats:italic>\n                    expression was increased in all five samples where it was detected, indicating its potential involvement in tumor cell motility and invasion. HSPs showed a mild increase in four out of five cases following cooling, potentially contributing to tumor cell resistance to cooling-induced apoptosis. Intraoperative mild cooling resulted in the downregulation of key proteins playing a role in invasion and metastasis. However, Elevated\n                    <jats:italic toggle=\"yes\">YB-1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">N-Cad<\/jats:italic>\n                    expression limits cooling's universal application. Further research is necessary to comprehend cooling-related transcriptome changes and their impact on patient outcomes.\n                  <\/jats:p>","DOI":"10.1089\/ther.2023.0060","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T11:47:12Z","timestamp":1702295232000},"page":"290-298","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intra Operative Mild Cooling of Large Tumors Reduces Their Invasive and Metastatic Functions While Increasing Their Resistance to Apoptosis"],"prefix":"10.1177","volume":"14","author":[{"given":"Noureddin","family":"Tavassoli","sequence":"first","affiliation":[{"name":"Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Ghahremani","sequence":"additional","affiliation":[{"name":"Nano Bio Electronic Devices Lab, Nano Electronic Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosar","family":"Namakin","sequence":"additional","affiliation":[{"name":"Nano Bio Electronic Devices Lab, Nano Electronic Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran."},{"name":"Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-5321","authenticated-orcid":false,"given":"Alvand","family":"Naserghandi","sequence":"additional","affiliation":[{"name":"Nano Bio Electronic Devices Lab, Nano Electronic Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran."},{"name":"Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Rouhollah","family":"Miri","sequence":"additional","affiliation":[{"name":"Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Abdolahad","sequence":"additional","affiliation":[{"name":"Nano Bio Electronic Devices Lab, Nano Electronic Center of Excellence, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.870820"},{"key":"e_1_3_3_3_1","first-page":"420","article-title":"Y-Box binding protein 1 expression in breast cancer and its correlation with hormone receptors and other prognostic markers","volume":"10","author":"Bansal T","year":"2018","unstructured":"Bansal T, , Tanveer N, , Singh UR, et al. 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