{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:32:12Z","timestamp":1793298732941,"version":"4.5.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Temperature management plays a critical role in the neurological recovery of cardiac arrest survivors. While advanced device-based temperature control systems are prevalent in high-resource settings, their implementation in low-resource environments remains a challenge. This study aimed to examine the impact of fever prevention on neurological outcomes in cardiac arrest survivors managed without device-based temperature control. We conducted a retrospective study of adult in-hospital cardiac arrest survivors at an academic institution from 2013 to 2020. Patients were included if they were \u226518 years old, survived for at least 72 hours post-return of spontaneous circulation (ROSC), and experienced cardiac arrest in inpatient wards, intensive care units, or the emergency department. Fever was defined as a rectal temperature \u226537.5\u00b0C, and neurological outcomes were assessed using the Cerebral Performance Category (CPC) scale at 1 month post-ROSC. A good neurological outcome was defined as CPC 1 or 2. Statistical analyses included chi-square tests and logistic regression to identify predictors of outcomes. Of the 427 patients included, 58.8% experienced fever, and 12.8% achieved a good neurological outcome. Patients with fever were significantly less likely to have favorable outcomes (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.01). Logistic regression revealed that each 1\u00b0C increase in body temperature beyond 37.5\u00b0C was associated with a 31% reduction in the likelihood of a good outcome (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.01). Other predictors of poor outcomes included prolonged low-flow states and higher pre-arrest frailty scores. Fever is strongly associated with poor neurological outcomes in cardiac arrest survivors, particularly in low-resource settings without device-based temperature management. Effective fever prevention strategies, such as intravenous antipyretics and physical cooling methods, should be prioritized to improve outcomes.\n                  <\/jats:p>","DOI":"10.1089\/ther.2024.0051","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T10:00:30Z","timestamp":1736935230000},"page":"213-219","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Fever Prevention and Neurological Recovery in In-Hospital Cardiac Arrest Survivors at a Limited-Resource Setting"],"prefix":"10.1177","volume":"15","author":[{"given":"Abdullah","family":"Bakhsh","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wijdan","family":"Bakhashwain","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alhazmi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salem","family":"Bahwireth","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Binmahfooz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Bakhribah","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadeel","family":"Alsufyani","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003289"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.04.006"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100591"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000387"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-023-02494-1"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-58468-y"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012689"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1906661"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resplu.2023.100538"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044285"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310519"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000079019.02601.90"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-020-00846-6"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-022-06620-5"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00302-9"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2020.09.012"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2021.02.010"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3174"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.16.2007"}],"container-title":["Therapeutic Hypothermia and Temperature Management"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ther.2024.0051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ther.2024.0051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ther.2024.0051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:28:20Z","timestamp":1777699700000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/ther.2024.0051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1089\/ther.2024.0051"],"URL":"https:\/\/doi.org\/10.1089\/ther.2024.0051","relation":{},"ISSN":["2153-7658","2153-7933"],"issn-type":[{"value":"2153-7658","type":"print"},{"value":"2153-7933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}