{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:09:43Z","timestamp":1777939783724,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Hypothermia and Temperature Management"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>\n                    Therapeutic hypothermia is a critical intervention in post-cardiac arrest care, yet the optimal cooling method remains debatable. This prospective, single-center study compared the efficacy of a novel craniocerebral hypothermia helmet with the Arctic Sun 5000 surface cooling system in post-cardiac arrest patients. Thirty-four comatose survivors of cardiac arrest were randomized to receive either craniocerebral hypothermia (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 17) or peripheral surface cooling (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 17). Target temperature management (32\u201334\u00b0C) was initiated within 30\u2013120 minutes of return of spontaneous circulation and maintained for 36\u201348 hours. Craniocerebral hypothermia demonstrated significantly faster cooling initiation (32.9 \u00b1 13.5 vs. 238 \u00b1 25.7 minutes,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001) compared with peripheral cooling, while both methods achieved similar target temperature maintenance. The craniocerebral group showed better preservation of renal function and electrolyte stability, with significantly lower increases in serum creatinine and urea levels (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001). Hospital stays were notably shorter in the craniocerebral group (13 \u00b1 7 vs. 24.29 \u00b1 31 days,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001). While both methods achieved comparable survival rates, the craniocerebral group exhibited a lower incidence of seizures (17.6% vs. 66.6%) and improved neurological outcomes based on Cerebral Performance Category scores though not reaching statistical significance. These findings suggest that craniocerebral hypothermia offers advantages in terms of rapid cooling initiation, physiological stability, and reduced hospital stay, representing a promising alternative for targeted temperature management in post-cardiac arrest care. The enhanced practicality and comparable efficacy of this approach warrant further investigation through larger multicenter trials.\n                  <\/jats:p>","DOI":"10.1089\/ther.2025.0006","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T22:08:56Z","timestamp":1741903736000},"page":"51-58","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Efficacy of Craniocerebral Hypothermia Helmet Versus Arctic Sun Surface Cooling System in Post-Cardiac Arrest Syndrome: A Prospective Comparative Study"],"prefix":"10.1177","volume":"16","author":[{"given":"Aydin","family":"Nadir","sequence":"first","affiliation":[{"name":"Department of Cardiology, Bezmialem Vakif University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Sari","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Bezmialem Vakif University, Istanbul, Turkey."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_3_2_2_1","first-page":"156","article-title":"Selective cerebral cooling and physiological responses in post-cardiac arrest care","volume":"41","author":"Anderson KM","year":"2023","unstructured":"Anderson KM, , Phillips R, , Thompson J, et al. Selective cerebral cooling and physiological responses in post-cardiac arrest care. Crit Care Med, 2023; 41:156\u2013163.","journal-title":"Crit Care Med"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003289"},{"key":"e_1_3_2_4_1","first-page":"244","article-title":"Early temperature management after cardiac arrest: A scientific statement from the International Liaison Committee on Resuscitation","volume":"132","author":"Callaway CW","year":"2015","unstructured":"Callaway CW, , Donnino MW, , Fink EL, et al. Early temperature management after cardiac arrest: A scientific statement from the International Liaison Committee on Resuscitation. Circulation, 2015; 132:244\u2013256.","journal-title":"Circulation"},{"key":"e_1_3_2_5_1","first-page":"78","article-title":"Blood-brain barrier integrity during therapeutic hypothermia: A mechanistic study","volume":"40","author":"Chen X","year":"2024","unstructured":"Chen X, , Wong KS, , Liu Y, et al. Blood-brain barrier integrity during therapeutic hypothermia: A mechanistic study. Neurocrit Care, 2024; 40:78\u201386.","journal-title":"Neurocrit Care"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100591"},{"key":"e_1_3_2_7_1","first-page":"125","article-title":"Contemporary approaches to therapeutic temperature management: A systematic review","volume":"52","author":"Davidson P","year":"2024","unstructured":"Davidson P, , Mitchell S, , Roberts K, et al. Contemporary approaches to therapeutic temperature management: A systematic review. Crit Care Med, 2024; 52:125\u2013137.","journal-title":"Crit Care Med"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012689"},{"key":"e_1_3_2_9_1","first-page":"108","article-title":"Autonomic function during selective head cooling versus systemic hypothermia","volume":"185","author":"Hughes JW","year":"2023","unstructured":"Hughes JW, , Parker SD, , Wilson ME, et al. Autonomic function during selective head cooling versus systemic hypothermia. Resuscitation, 2023; 185:108\u2013116.","journal-title":"Resuscitation"},{"key":"e_1_3_2_10_1","first-page":"875","article-title":"Effect of cooling method selection on post-cardiac arrest outcomes","volume":"46","author":"Kim F","year":"2020","unstructured":"Kim F, , Nichol G, , Maynard C, et al. Effect of cooling method selection on post-cardiac arrest outcomes. Intensive Care Med, 2020; 46:875\u2013883.","journal-title":"Intensive Care Med"},{"key":"e_1_3_2_11_1","first-page":"1378","article-title":"Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: A randomized clinical trial","volume":"323","author":"Kim F","year":"2020","unstructured":"Kim F, , Nichol G, , Maynard C, et al. Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: A randomized clinical trial. JAMA, 2020; 323:1378\u20131387.","journal-title":"JAMA"},{"key":"e_1_3_2_12_1","first-page":"1375","article-title":"Targeted temperature management for 48 vs 24 hours after out-of-hospital cardiac arrest","volume":"327","author":"Kirkegaard H","year":"2022","unstructured":"Kirkegaard H, , S\u00f8reide E, , de Haas I, et al. Targeted temperature management for 48 vs 24 hours after out-of-hospital cardiac arrest. JAMA, 2022; 327:1375\u20131384.","journal-title":"JAMA"},{"key":"e_1_3_2_13_1","first-page":"23","article-title":"Temperature fluctuations and neurological outcomes in post-cardiac arrest care","volume":"14","author":"Martinez-Garcia A","year":"2024","unstructured":"Martinez-Garcia A, , Rodriguez-Santos C, , Lopez R, et al. Temperature fluctuations and neurological outcomes in post-cardiac arrest care. Ther Hypothermia Temp Manag, 2024; 14:23\u201331.","journal-title":"Ther Hypothermia Temp Manag"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1502173"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310519"},{"key":"e_1_3_2_16_1","first-page":"45","article-title":"Economic analysis of cooling methods in post-cardiac arrest care","volume":"28","author":"Parker SD","year":"2024","unstructured":"Parker SD, , Thompson JL, , Anderson KM, et al. Economic analysis of cooling methods in post-cardiac arrest care. Crit Care, 2024; 28:45\u201352.","journal-title":"Crit Care"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181aa5241"},{"key":"e_1_3_2_18_1","first-page":"92","article-title":"Targeted brain cooling: Advances and future directions","volume":"184","author":"Reynolds JC","year":"2023","unstructured":"Reynolds JC, , Rittenberger JC, , Menegazzi JJ. Targeted brain cooling: Advances and future directions. Resuscitation, 2023; 184:92\u201399.","journal-title":"Resuscitation"},{"key":"e_1_3_2_19_1","first-page":"156","article-title":"Post-arrest seizures and neurological recovery: A prospective analysis","volume":"38","author":"Rodriguez-Santos C","year":"2023","unstructured":"Rodriguez-Santos C, , Martinez A, , Garcia R, et al. Post-arrest seizures and neurological recovery: A prospective analysis. Neurocrit Care, 2023; 38:156\u2013164.","journal-title":"Neurocrit Care"},{"key":"e_1_3_2_20_1","first-page":"76","article-title":"Temperature management in cardiac arrest: A cost-effectiveness analysis","volume":"183","author":"Thompson K","year":"2023","unstructured":"Thompson K, , Williams L, , Chen A, et al. Temperature management in cardiac arrest: A cost-effectiveness analysis. Resuscitation, 2023; 183:76\u201384.","journal-title":"Resuscitation"},{"key":"e_1_3_2_21_1","first-page":"234","article-title":"Time to target temperature and outcomes after cardiac arrest: A meta-analysis","volume":"49","author":"Wang Q","year":"2023","unstructured":"Wang Q, , Li Y, , Zhang L, et al. Time to target temperature and outcomes after cardiac arrest: A meta-analysis. Intensive Care Med, 2023; 49:234\u2013242.","journal-title":"Intensive Care Med"},{"key":"e_1_3_2_22_1","first-page":"1234","article-title":"Neuroinflammatory responses during therapeutic hypothermia","volume":"43","author":"Williams JM","year":"2023","unstructured":"Williams JM, , Roberts KE, , Mitchell SA, et al. Neuroinflammatory responses during therapeutic hypothermia. J Cereb Blood Flow Metab, 2023; 43:1234\u20131242.","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_3_2_23_1","first-page":"89","article-title":"Electrolyte disturbances during therapeutic hypothermia: Impact on outcomes","volume":"28","author":"Wilson D","year":"2024","unstructured":"Wilson D, , Chen A, , Brooks S, et al. Electrolyte disturbances during therapeutic hypothermia: Impact on outcomes. Crit Care, 2024; 28:89\u201397.","journal-title":"Crit Care"},{"key":"e_1_3_2_24_1","first-page":"150","article-title":"Surface versus endovascular cooling: A comparative analysis of complications and outcomes","volume":"22","author":"Zhang L","year":"2016","unstructured":"Zhang L, , Liu Y, , Wang J, et al. Surface versus endovascular cooling: A comparative analysis of complications and outcomes. Crit Care, 2016; 22:150.","journal-title":"Crit Care"},{"key":"e_1_3_2_25_1","first-page":"167","article-title":"Rapid cooling strategies in post-cardiac arrest care: A systematic review and meta-analysis","volume":"168","author":"Zhang L","year":"2021","unstructured":"Zhang L, , Wang Q, , Yang R, et al. Rapid cooling strategies in post-cardiac arrest care: A systematic review and meta-analysis. 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