{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:28:59Z","timestamp":1792416539326,"version":"4.4.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>We describe a 31-year-old woman who had ingested minocycline for 18 months prior to presenting with hyperthyroidism and a palpable thyroid nodule. There was no evidence of Graves' disease or autonomous nodule on thyroid scintigraphy, and a clinical diagnosis of thyroiditis was made. Fine-needle aspiration biopsy of the palpable lesion suggested papillary carcinoma, and the patient underwent a total thyroidectomy. Intraoperatively, the thyroid gland was found to have a striking black discoloration. Subsequent histological examination revealed the accumulation of pigment globules within the apical cytoplasm of the follicular cells, and associated findings of a drug-induced thyroiditis. The tumor nodule showed features of infarction and was felt to represent a necrotic papillary microcarcinoma. We postulate that in addition to causing black thyroid pigmentation, chronic minocycline use in our patient resulted in thyroiditis and subsequent hyperthyroidism. The papillary microcarcinoma was probably a coincidental finding.<\/jats:p>","DOI":"10.1089\/thy.2008.0048","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T03:24:20Z","timestamp":1216265060000},"page":"795-797","source":"Crossref","is-referenced-by-count":15,"title":["Drug-Induced Thyroiditis and Papillary Carcinoma in a Minocycline-Pigmented Black Thyroid Gland"],"prefix":"10.1177","volume":"18","author":[{"given":"Lyndal","family":"Tacon","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles T.K.","family":"Tan","sequence":"additional","affiliation":[{"name":"National University Hospital, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit, Royal North Shore Hospital, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Gill","sequence":"additional","affiliation":[{"name":"University of Sydney and Department of Pathology, Royal North Shore Hospital, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Sywak","sequence":"additional","affiliation":[{"name":"University of Sydney and Endocrine Surgical Unit, Royal North Shore Hospital, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Fulcher","sequence":"additional","affiliation":[{"name":"University of Sydney and Department of Endocrinology, Royal North Shore Hospital, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2008,7,1]]},"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2008.0048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2008.0048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:38:50Z","timestamp":1777700330000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/thy.2008.0048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1089\/thy.2008.0048"],"URL":"https:\/\/doi.org\/10.1089\/thy.2008.0048","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}