{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:17:59Z","timestamp":1777940279390,"version":"3.51.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      The ability of sialagogues to increase or decrease radiation induced-sialoadenitis and\/or xerostomia after therapeutic administration of\n                      <jats:sup>131<\/jats:sup>\n                      I is controversial. To evaluate this we measured the radiopharmacokinetics of\n                      <jats:sup>123<\/jats:sup>\n                      I in the parotid glands (PGs) after its administration of lemon juice (LJ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A retrospective review was performed on all patients who had a salivary gland scan performed before\n                      <jats:sup>131<\/jats:sup>\n                      I therapy between July 2008 and April 2009 at the Washington Hospital Center. Two hours after\n                      <jats:sup>123<\/jats:sup>\n                      I was given orally, dynamic scintigraphy was initiated. Five milliliters of LJ was given 5 minutes later. Then, the patient was imaged for 1 hour (phase 1) at which point the sequence was repeated (phase 2). Twenty-three patients were studied. For each PG, the presence or absence of uptake was assessed, and based on background corrected counts, the mean, range, and standard deviation were determined for multiple radiopharmacokinetic parameters such as (i) percent radioiodine washout, (ii) time from LJ administration to re-accumulation of radioiodine to pre-LJ activity, and (iii) percent reduction in radiation absorbed dose to the PGs if LJ had been re-administered at the time the radioiodine activity re-accumulated to the pre-LJ activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The mean\u2009\u00b1\u2009one standard deviation and range for percent washout were 84%\u2009\u00b1\u200918% (35%\u2013100%) and 83%\u2009\u00b1\u200921% (37%\u2013100%) in phase 1 and 2, respectively. The times from LJ to re-accumulation of the radioiodine to the pre-LJ activity were 21\u2009\u00b1\u200910 minutes (4\u201345 minutes) and 40\u2009\u00b1\u200914 minutes (12\u201362 minutes) for phase 1 and 2, respectively. The estimated percent reduction in radiation absorbed dose to the PGs following the first and second administration of LJ was 37%\u2009\u00b1\u200914% (13%\u201393%) and 47%\u2009\u00b1\u200916% (21%\u201397%), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The washout of radioiodine from the PGs is rapid but transient. Early repeat administration may result in continued and cumulative reduction of radiation absorbed dose in the PGs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2009.0429","type":"journal-article","created":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T08:40:12Z","timestamp":1285922412000},"page":"1113-1119","source":"Crossref","is-referenced-by-count":37,"title":["Radiopharmacokinetics of Radioiodine in the Parotid Glands After the Administration of Lemon Juice"],"prefix":"10.1177","volume":"20","author":[{"given":"Douglas","family":"Van Nostrand","sequence":"first","affiliation":[{"name":"Washington Hospital Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varalakshmi","family":"Bandaru","sequence":"additional","affiliation":[{"name":"Washington Hospital Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyam","family":"Chennupati","sequence":"additional","affiliation":[{"name":"Washington Hospital Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Wexler","sequence":"additional","affiliation":[{"name":"Washington Hospital Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanchan","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Washington Hospital Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Atkins","sequence":"additional","affiliation":[{"name":"Washington Hospital Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihriye","family":"Mete","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurudev","family":"Gadwale","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,10,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0236"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/105072503321582060"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59259-995-0_52"},{"key":"e_1_3_3_5_2","first-page":"261","article-title":"Dose lemon candy decrease salivary gland damage after radioiodine therapy for thyroid cancer?","volume":"46","author":"Nakada K","year":"2005","unstructured":"Nakada K, , Ishibashi T, , Takei T, , Hirata K, , Shinohara K, , Katoh S, , Zhao S, , Tamaki N, , Noguchi Y, , Noguchi S. 2005. Dose lemon candy decrease salivary gland damage after radioiodine therapy for thyroid cancer? J Nucl Med, 46:261\u2013266.","journal-title":"J Nucl Med"},{"key":"e_1_3_3_6_2","first-page":"2118","article-title":"Does lemon candy decreased salivary gland damage after radioiodine therapy for thyroid cancer? Letter to the editor","volume":"46","author":"Lam MGEH","year":"2005","unstructured":"Lam MGEH, , van Isselt JW. 2005. Does lemon candy decreased salivary gland damage after radioiodine therapy for thyroid cancer? Letter to the editor. J Nucl Med, 46:2118\u20132119.","journal-title":"J Nucl Med"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.049411"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0381"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.071449"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.10.11.928"},{"key":"e_1_3_3_11_2","first-page":"447","article-title":"Secretion of radioiodine in digestive juices and milk in man","volume":"11","author":"Honour AJ","year":"1952","unstructured":"Honour AJ, , Myant NB, , Rowlands EN. 1952. Secretion of radioiodine in digestive juices and milk in man. Clin Sci, 11:447\u2013462.","journal-title":"Clin Sci"},{"key":"e_1_3_3_12_2","first-page":"500","article-title":"Kinetics of perrhenate uptake and comparative biodistribution of perrhenate, pertechnetate and iodide by NaI symporter\u2014expressing tissues in vivo","volume":"45","author":"Zuckier LS","year":"2004","unstructured":"Zuckier LS, , Dohan O, , Li Y, , Chang CJ, , Carrasco N, , Dadachova E. 2004. Kinetics of perrhenate uptake and comparative biodistribution of perrhenate, pertechnetate and iodide by NaI symporter\u2014expressing tissues in vivo. J Nucl Med, 45:500\u2013507.","journal-title":"J Nucl Med"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/105072502753522356"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/thy.2009.0429","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2009.0429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2009.0429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:43:54Z","timestamp":1777700634000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/thy.2009.0429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1089\/thy.2009.0429"],"URL":"https:\/\/doi.org\/10.1089\/thy.2009.0429","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}