{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:19:08Z","timestamp":1777940348704,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2011,1]]},"abstract":"\n Background:<\/jats:title>\n Pretibial myxedema (PM) is an uncommon and characteristic manifestation of Graves' disease (GD), with local autoimmune reaction in cutaneous tissue. The treatment of PM is a clinical challenge. We herein report a patient with PM who achieved complete remission by multipoint subcutaneous injection of long-acting glucocorticid.<\/jats:p>\n <\/jats:sec>\n \n Summary:<\/jats:title>\n A 38-year-old man presented with an 18-month history of GD and a 1-year history of PM. Physical examination revealed mildly prominent eyes, diffuse enlargement of the thyroid gland, and PM of both lower extremities. The patient was treated with triamcinolone acetonide by multipoint subcutaneous injections in a combined dose of 20\u2009mg in each lower extremity administered every 25\u201328 days. The injection was started from the borderline of the lesions and normal skin by selecting 4 to 5 points per leg for each course and then moving to other parts in subsequent courses of treatment. The depth of needle insertion was 0.5\u20131.0\u2009cm. The patient's PM achieved complete remission in both lower extremities after an approximately 6-month period that included seven courses of treatment with a total dosage of 280\u2009mg triamcinolone acetonide.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Our experience with this patient suggests that multipoint subcutaneous injection of long-acting glucocorticid is a safe, effective, and convenient treatment of PM in patients with GD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/thy.2010.0268","type":"journal-article","created":{"date-parts":[[2010,12,17]],"date-time":"2010-12-17T00:03:52Z","timestamp":1292544232000},"page":"83-85","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Multipoint Subcutaneous Injection of Long-Acting Glucocorticid as a Cure for Pretibial Myxedema"],"prefix":"10.1177","volume":"21","author":[{"given":"Aimin","family":"Deng","sequence":"first","affiliation":[{"name":"Guangzhou General Hospital of Guangzhou Military Command Region","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Song","sequence":"additional","affiliation":[{"name":"Guangzhou General Hospital of Guangzhou Military Command Region","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,1,1]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"438","article-title":"Dermopathy of Graves' disease (pretibial myxedema): long-term outcome","volume":"87","author":"Schwartz KM","year":"2002","unstructured":"Schwartz KM, , Fatourechi V, , Ahmed DD, , Pond GR. 2002. Dermopathy of Graves' disease (pretibial myxedema): long-term outcome. J Clin Endocrinol Metab, 87:438\u2013446.","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0020"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1460035"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1985.00360010153024"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1980.tb01188.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200506050-00003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199401000-00001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555726971"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1998.tb02394.x"},{"key":"e_1_3_2_11_2","first-page":"16","article-title":"Cakir M 2007 Successful combined pentoxifylline, intralesional triamcinolone acetonide treatment of severe pretibial myxedema","volume":"13","author":"Engin B","unstructured":"Engin B, , Gumusel M, , Ozdemir M. Cakir M 2007 Successful combined pentoxifylline, intralesional triamcinolone acetonide treatment of severe pretibial myxedema. Dermatol Online J, 13:16.","journal-title":"Dermatol Online J"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/thy.2010.0268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2010.0268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2010.0268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:46:21Z","timestamp":1777700781000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/thy.2010.0268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["10.1089\/thy.2010.0268"],"URL":"https:\/\/doi.org\/10.1089\/thy.2010.0268","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}