{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:44:26Z","timestamp":1792896266135,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ultrasound-guided thermal laser ablation (LA) is a nonsurgical technique that has been proposed, but not fully assessed, for papillary thyroid microcarcinoma (PTMC) treatment. The objectives of this study were to evaluate the clinical feasibility of LA on PTMC as a primary treatment and to prove histologically the absence of residual viable tumor after LA procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Three patients with a Thy 6 diagnosis at fine-needle aspiration cytology with a single PTMC smaller than 10\u2009mm volunteered after full explanation of the protocol. At ultrasound examination, patients had no extrathyroid extension and no evidence of lymph node metastasis. Patients underwent percutaneous ultrasound-assisted LA of the PTMC in the operating room under general anesthesia. One 300\u2009\u03bcm plane-cut optic fiber was inserted through the sheath of 21G Chiba needle, exposing 5\u2009mm of the nude fiber in direct contact with tumor tissue, and connected with a laser source operating at 1.064\u2009\u03bcm with 3 W output power. Total energy delivery was 1800\u2009J. The surgeon directly started a standard total thyroidectomy. During surgical inspection, no remarkable laser sign was observed in the muscles, the perithyroidal tissues, or the recurrent laryngeal nerves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Conventional histology showed destructured and carbonized tissue. Lack of vitality was demonstrated by complete loss of TTF1 and antimitochondria antibody expression in the whole ablated area and in the rim of normal tissue surrounding the tumor.\n                      <jats:italic toggle=\"yes\">BRAF<\/jats:italic>\n                      V600E mutation was detected in cases 1 and 2. Furthermore, in cases 2 and 3, incidental papillary microfoci were found. A lymph node micrometastasis (200\u2009\u03bcm) was observed in case 2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study demonstrates that percutaneous LA is technically feasible for complete PTMC destruction. Now, LA may be useful in selected patients with PTMC, either when the surgeon or a patient refuses surgery, or when the patient is at high risk for an operation. LA may become a primary choice of treatment for PTMC only if future new knowledge would permit preoperative recognition of multifocality and lymph node metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2013.0279","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T12:19:28Z","timestamp":1377519568000},"page":"1578-1582","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":100,"title":["Ultrasound-Guided Percutaneous Laser Ablation of Papillary Thyroid Microcarcinoma: A Feasibility Study on Three Cases with Pathological and Immunohistochemical Evaluation"],"prefix":"10.1177","volume":"23","author":[{"given":"Roberto","family":"Valcavi","sequence":"first","affiliation":[{"name":"Arcispedale Santa Maria Nuova and Clinical Cancer Research Institute (IRCCS)","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Piana","sequence":"additional","affiliation":[{"name":"Arcispedale Santa Maria Nuova and Clinical Cancer Research Institute (IRCCS)","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio Stecconi","family":"Bortolan","sequence":"additional","affiliation":[{"name":"Arcispedale Santa Maria Nuova and Clinical Cancer Research Institute (IRCCS)","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Lai","sequence":"additional","affiliation":[{"name":"Arcispedale Santa Maria Nuova and Clinical Cancer Research Institute (IRCCS)","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verter","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Arcispedale Santa Maria Nuova and Clinical Cancer Research Institute (IRCCS)","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Negro","sequence":"additional","affiliation":[{"name":"\u201cV. Fazzi\u201d Hospital","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,12,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2321021368"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0189"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-11-0220"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000217685.85467.2d"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2991"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0447"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20830"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1526"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-012-9192-0"},{"key":"e_1_3_3_11_2","first-page":"87","volume-title":"Thyroid","author":"Edge SB","year":"2010","unstructured":"Edge SB, , Byrd DR, , Compton CC, , Fritz AG, , Frederick LG, , Trotti A (eds) 2010. Thyroid. In: AJCC Cancer Staging Manual. Seventh edition. Springer, New York, pp 87\u201396."},{"key":"e_1_3_3_12_2","first-page":"674","article-title":"Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 19:1167\u20131214","volume":"20","author":"Cooper DS","year":"2009","unstructured":"Cooper DS, , Doherty GM, , Haugen BR, , Kloos RT, , Lee SL, , Mandel SJ, , Mazzaferri EL, , McIver B, , Pacini F, , Schlumberger M, , Sherman SI, , Steward DL, , Tuttle RM. 2009. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 19:1167\u20131214. Erratum in: Thyroid, 2010, 20:674\u2013675.","journal-title":"Erratum in: Thyroid"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0303-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21429"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.10.088"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880501"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2010.06.023"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11642"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e31825439bc"},{"key":"e_1_3_3_20_2","first-page":"596","article-title":"Immunocytochemical characterization of a monoclonal antibody directed against mitochondria reactive in paraffin-embedded sections","volume":"4","author":"Weiss LM","year":"1991","unstructured":"Weiss LM, , Gaffey MJ, , Warhol MJ, , Mehta P, , Bonsib SM, , Bruder E, , Santos E, , Mederios LJ. 1991. 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