{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:16:18Z","timestamp":1782774978487,"version":"3.54.5"},"reference-count":33,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Propylthiouracil (PTU) used in the treatment of maternal hyperthyroidism in early pregnancy may be associated with a higher prevalence of birth defects in the face and neck region and in the urinary system but the severity of these complications remains to be elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Review of hospital-registered cases of birth defects in the face and neck region and in the urinary system after PTU exposure in early pregnancy. We obtained information on maternal redeemed prescription of PTU and child diagnosis of birth defect from nationwide registers for all children born in Denmark between 1996 and 2008 (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =817,093). The children were followed until December 31, 2010 (median age, 8.3 years) and the Cox proportional hazards model was used to estimate adjusted hazard ratio (HR) with 95% confidence interval (CI) for having a birth defect after PTU exposure versus nonexposed children (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =811,730).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Fourteen cases of birth defects were identified in the face and neck region and in the urinary system after PTU exposure in early pregnancy; 11 children were exposed to PTU only (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =564), whereas 3 children were born to mothers who switched from methimazole (MMI)\/carbimazole (CMZ) to PTU in early pregnancy (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      =159). Among children exposed to PTU only, the adjusted HR for having a birth defect in the face and neck region was 4.92 (95% CI 2.04\u201311.86) and in the urinary system 2.73 (1.22\u20136.07). Looking into details of the 14 cases, 7 children were diagnosed with a birth defect in the face and neck region (preauricular and branchial sinus\/fistula\/cyst) and 7 children had a birth defect in the urinary system (single cyst of kidney and hydronephrosis). Surgical treatment was registered in 6 of the cases with a birth defect in the face and neck region and 3 of the cases with a birth defect in the urinary system. Two of the children with a birth defect in the urinary system also had other birth defects (genital organs).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We report details on possible PTU-associated birth defects. They tend to be less severe than the defects observed after MMI\/CMZ exposure. Yet, the majority of affected children had to undergo surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2014.0150","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T11:06:09Z","timestamp":1403694369000},"page":"1533-1540","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":90,"title":["Severity of Birth Defects After Propylthiouracil Exposure in Early Pregnancy"],"prefix":"10.1177","volume":"24","author":[{"given":"Stine Linding","family":"Andersen","sequence":"first","affiliation":[{"name":"Aalborg University Hospital","place":["Denmark"]},{"name":"Aalborg University","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Olsen","sequence":"additional","affiliation":[{"name":"Aarhus University","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Sen","family":"Wu","sequence":"additional","affiliation":[{"name":"Aarhus University","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Laurberg","sequence":"additional","affiliation":[{"name":"Aalborg University Hospital","place":["Denmark"]},{"name":"Aalborg University","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra042972"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3549"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0135"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2831"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000342920"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2860"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e3283565b49"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e328357f3d5"},{"key":"e_1_3_3_10_2","first-page":"135","article-title":"Low birth weight in children born to mothers with hyperthyroidism and high birth weight in hypothyroidism, whereas preterm birth is common in both conditions: a Danish National Hospital Register study","volume":"2","author":"Andersen SL","year":"2013","unstructured":"Andersen SL, , Olsen J, , Wu CS, , Laurberg P. 2013. 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