{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:25:40Z","timestamp":1777940740138,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The aim of this prospective study was to investigate the effect of salivary stimulation therapy using pilocarpine (a cholinergic agent) on chronic radioactive iodine (RAI)-induced sialadenitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Sixty-one patients with a diagnosis of chronic RAI-induced sialadenitis after thyroidectomy and RAI therapy were enrolled in this prospective study. Patients received salivary stimulation therapy with pilocarpine (5\u2009mg, 3 times daily) over a 3-month period. Subjective symptom scores were assessed using self-reported questionnaires. Salivary flow rates (SFRs) were measured and salivary gland scintigraphy (SGS) was performed to evaluate objective salivary gland functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      After salivary stimulation therapy, subjective symptom scores were significantly improved (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.002), but posttreatment unstimulated and stimulated SFRs did not differ significantly from pretreatment values. SGS parameters, that is, uptake ratio (UR), maximum accumulation (MA), T\n                      <jats:sub>min<\/jats:sub>\n                      , and maximum secretion (MS) of parotid and submandibular glands were nonsignificantly different after salivary stimulation therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The study shows that salivary stimulation therapy may reduce the subjective symptoms of RAI-induced chronic sialadenitis but does not significantly induce functional restoration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2014.0525","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T04:20:55Z","timestamp":1427430055000},"page":"839-845","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Salivary Secretion Stimulation on the Treatment of Chronic Radioactive Iodine-Induced Sialadenitis"],"prefix":"10.1177","volume":"25","author":[{"given":"Jeong-Seok","family":"Choi","sequence":"first","affiliation":[{"name":"Inha University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Bin","family":"Hong","sequence":"additional","affiliation":[{"name":"Inha University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Young","family":"Hyun","sequence":"additional","affiliation":[{"name":"Inha University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Yol","family":"Lim","sequence":"additional","affiliation":[{"name":"Inha University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Mo","family":"Kim","sequence":"additional","affiliation":[{"name":"Inha University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/105072503321582060"},{"key":"e_1_3_3_3_2","first-page":"1551","article-title":"Intermediate and long-term side effects of high-dose radioiodine therapy for thyroid carcinoma","volume":"39","author":"Alexander C","year":"1998","unstructured":"Alexander C, , Bader JB, , Schaefer A, , Finke C, , Kirsch CM. 1998. 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