{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:36:56Z","timestamp":1789803416726,"version":"4.0.1"},"reference-count":27,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Iodinated contrast media (ICM) is a source of excess iodine that may induce thyroid dysfunction. A prospective cohort study was conducted to assess the effects of ICM on urinary iodine clearance and serum thyroid function tests (TFTs) in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this prospective cohort study of 54 adults undergoing elective computed tomography (CT) scans at an academic medical center, serial urinary iodine concentrations (UIC) and serum TFTs were obtained until UIC normalized following ICM administration. Thyroid volume\/nodularity were assessed by ultrasound. Associations between covariates and peak UIC, duration for UIC to peak and normalize, and thyroid dysfunction risk were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean\u00b1standard deviation (\n                      <jats:italic toggle=\"yes\">SD<\/jats:italic>\n                      ) iodine administered was 34.6\u00b16.0\u2009g. Baseline median (range) UIC was 105.1 (17.0\u2013866.1)\u2009\u03bcg\/L, and serum thyrotropin (TSH) concentration was 1.26 (0.5\u201311.2) mIU\/L. The mean\u00b1\n                      <jats:italic toggle=\"yes\">SD<\/jats:italic>\n                      times to achieve peak UIC (median [range]: 3519 [233\u2013157,500]\u2009\u03bcg\/L] and normalized UIC were 1.1\u00b10.5 and 5.2\u00b14.0 weeks, respectively. Four subjects had elevated baseline TSH, and one had missing baseline TSH values. Of the remaining 49 subjects, 11 (22%) developed an abnormal TSH within one to four weeks (six elevated and five decreased). Administered iodine amount correlated with peak UIC following ICM administration (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.001). Increasing age and administered iodine amount predicted peak UIC (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      =0.024 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt;0.001, respectively). Age, sex, race\/ethnicity, smoking status, family history of thyroid disease, personal or family history of thyroid autoimmunity, thyroid volume, presence of thyroid nodules \u22651\u2009cm, iodine dose, baseline UIC, and baseline TFTs were not predictive of durations to achieve peak or normalized UIC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Peak UIC occurred at 1.1 weeks and normalized by 5.2 weeks following ICM administration for outpatient CT scans. Because thyroid dysfunction developed in 22% of individuals following a single ICM dose, monitoring of thyroid function should be considered in at-risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2015.0024","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T04:28:41Z","timestamp":1425616121000},"page":"471-477","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Urinary Iodine Excretion and Serum Thyroid Function in Adults After Iodinated Contrast Administration"],"prefix":"10.1177","volume":"25","author":[{"given":"Sun Y.","family":"Lee","sequence":"first","affiliation":[{"name":"Boston University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donny L.F.","family":"Chang","sequence":"additional","affiliation":[{"name":"Reliant Medical Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"He","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth N.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis E.","family":"Braverman","sequence":"additional","affiliation":[{"name":"Boston University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Leung","sequence":"additional","affiliation":[{"name":"UCLA David Geffen School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,5,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2004.03.001"},{"key":"e_1_3_3_3_2","unstructured":"Otten JJ Hellwig JP Meyers LD. 2006. DRI Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. National Academies Press Washington DC."},{"key":"e_1_3_3_4_2","unstructured":"WHO UNICEF ICCIDD 2007 Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination: A Guide for Programme Managers. Third edition. 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