{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:40:45Z","timestamp":1789767645425,"version":"4.0.1"},"reference-count":45,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Increased thyrotropin (TSH) levels and free triiodothyronine to free thyroxine (fT3:fT4) ratios, even within the euthyroid range, have been associated with cardiometabolic risk factors in adults but are less characterized in youth. This study sought to determine relations between TSH, thyroid hormones, and cardiometabolic risk factors in euthyroid adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Data were extracted from the United States National Health and Nutrition Examination Survey, 2007\u20132010, for univariate and multivariate analyses of TSH, thyroid hormones, body mass index (BMI), blood pressure, lipids, and glucose metabolism. Subjects aged 12\u201318 years, with normal TSH and antithyroid peroxidase antibody levels, and without a history of thyroid disease, diabetes, or treatment of hypertension\/dyslipidemia (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091167) were included. TSH and thyroid hormones were assessed for impact on BMI Z-score, systolic blood pressure (SBP) diastolic blood pressure, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and glucose metabolism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Univariate analyses revealed positive linear relations between TSH and SBP, TC, fasting and two-hour glucose, and homeostasis model assessment of insulin resistance (HOMA-IR). The fT3:fT4 ratio negatively correlated with high-density lipoprotein cholesterol but positively with BMI Z-score, SBP, triglycerides, fasting and two-hour glucose, fasting insulin, and HOMA-IR. In multivariate analyses controlling for age, sex, race\/ethnicity, and BMI Z-score, relations between TSH and both TC and fasting glucose remained significant, and the fT3:fT4 ratio was positively associated with fasting glucose and HOMA-IR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In an unselected population of euthyroid U.S. adolescents, TSH and thyroid hormones correlate with multiple cardiometabolic risk factors, with age- and sex-independent effects on cholesterol and glucose metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2016.0055","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:58:32Z","timestamp":1473209912000},"page":"1441-1449","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":44,"title":["Thyrotropin Levels Are Associated with Cardiometabolic Risk Factors in Euthyroid Adolescents"],"prefix":"10.1177","volume":"26","author":[{"given":"Trang N.","family":"Le","sequence":"first","affiliation":[{"name":"Virginia Commonwealth University"},{"name":"Virginia Commonwealth University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco S.","family":"Celi","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Edmond P.","family":"Wickham","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University"},{"name":"Virginia Commonwealth University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(05)70281-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.3.8165"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0748730414557634"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031641"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12092"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0170"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0455"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1180"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0259"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02333"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2208"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0626"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1315"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0205"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0067"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12538"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0103"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1718"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02874.x"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034979"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0447"},{"key":"e_1_3_3_23_2","first-page":"74","article-title":"Peripheral autoregulation of thyroxine to triiodothyronine conversion in man","volume":"14","author":"Nicoloff JT","year":"1984","unstructured":"Nicoloff JT, , Lum SM, , Spencer CA, , Morris R. 1984. Peripheral autoregulation of thyroxine to triiodothyronine conversion in man. Horm Metab Res Suppl, 14:74\u201379.","journal-title":"Horm Metab Res Suppl"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1784"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0314"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0180"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0110"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1441"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2768"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4466"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0077"},{"key":"e_1_3_3_32_2","first-page":"1","article-title":"National health and nutrition examination survey: plan and operations, 1999\u20132010. National Center for Health Statistics","volume":"56","author":"Zipf G","year":"2013","unstructured":"Zipf G, , Chiappa M, , Porter KS, , Ostchega Y, , Lewis BG, , Dostal J. 2013. National health and nutrition examination survey: plan and operations, 1999\u20132010. National Center for Health Statistics. Vital Health Stat 1, 56:1\u201337.","journal-title":"Vital Health Stat 1"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2007.00271.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP09176.OR"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0005"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-015-0011-x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1169"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1246184"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2001.158"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00030.2013"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0055"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0981"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004990"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004310051117"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.11.2444"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/thy.2016.0055","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2016.0055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2016.0055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:01:56Z","timestamp":1777586516000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/thy.2016.0055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1089\/thy.2016.0055"],"URL":"https:\/\/doi.org\/10.1089\/thy.2016.0055","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]}}}