{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:41:47Z","timestamp":1785404507752,"version":"3.56.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Follicular-patterned thyroid nodules predominantly composed of macrofollicular structures without nuclear atypia are generally regarded as benign (i.e., hyperplastic nodules or follicular adenomas). In line with this concept, fine-needle aspiration cytology (FNAC) also assigns a benign connotation to the presence of macrofollicular structures, unless thyrocytes present papillary thyroid carcinoma (PTC)-related nuclear features that raise the possibility of a macrofollicular variant of PTC. However, cases showing macrofollicular architecture, capsular invasion, and no PTC features can also be observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We describe the clinical, cytological, histological, and molecular genetic features of four cases of encapsulated follicular neoplasms that presented histologically with a predominant (&gt;70%) macrofollicular architecture, but which also showed clear signs of capsular invasion, and thus were classified as macrofollicular variant of follicular thyroid carcinoma (MV-FTC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Cytologically, macrofollicular structures were identified in all cases, leading to a benign FNAC diagnosis in three of the four cases. Due to increasing nodule size, thyroidectomy was performed in all cases. Histology showed focal and limited capsular invasion, without vascular invasion. Next-generation sequencing (custom 394 gene panel) of each tumor compared with matched normal DNA revealed a total of 7 somatic variants, including dual (likely biallelic) mutations in the\n                      <jats:italic toggle=\"yes\">DICER1<\/jats:italic>\n                      gene in 2 patients. The clinical outcome was excellent in all cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Similar to the classical minimally invasive follicular thyroid carcinoma, MV-FTC appears to behave indolently. MV-FTC has a high rate of false-negative FNAC results, but MV-FTC is very rare (&lt;0.05% of all thyroidectomies) and apparently has an indolent behavior. Further studies comprising larger series are necessary to better clarify the biology of this diagnostically challenging rare tumor.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2018.0607","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T09:56:25Z","timestamp":1573206985000},"page":"72-80","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Macrofollicular Variant of Follicular Thyroid Carcinoma: A Rare Underappreciated Pitfall in the Diagnosis of Thyroid Carcinoma"],"prefix":"10.1177","volume":"30","author":[{"given":"Massimo","family":"Bongiovanni","sequence":"first","affiliation":[{"name":"Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerasimos P.","family":"Sykiotis","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"La Rosa","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Bisig","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounir","family":"Trimech","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Missiaglia","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Gremaud","sequence":"additional","affiliation":[{"name":"ADMED Pathology, Neuchatel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilma","family":"Salvatori Chappuis","sequence":"additional","affiliation":[{"name":"ADMED Pathology, Neuchatel, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"De Vito","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Geneva University Hospital, Geneva, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amedeo","family":"Sciarra","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Foulkes","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, McGill University, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pusztaszeri","sequence":"additional","affiliation":[{"name":"Department of Pathology, McGill University, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.53"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP14466.DSCR"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179387"},{"key":"e_1_3_5_5_2","first-page":"92","volume-title":"World Health Organization Classification of Tumours of Endocrine Organs","author":"LiVolsi V","year":"2017","unstructured":"LiVolsi V, , Abdulkader Nallib I, , Baloch ZW, , Bartolazzi A, , Chan JKC, , DeLellis RA, , El-Naggar AK, , Eloc C, , Eng C, , Fagin JA, , Ghossein RA, , Giordano TJ, , Kondo T, , Lloyd RV, , Mete O, , Nikiforov YE, , Nonaka D, , Paschke R, , Perren A, , Rosai J, , Sadow PM, , Schneider AB, , Sobrinho Simoes M, , Tallini G, , Williams MD. 2017. Follicular thyroid carcinoma. In: Lloyd RV, , Osamura RY, , Kloppel G, , Rosai J (eds) World Health Organization Classification of Tumours of Endocrine Organs. 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