{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:25:00Z","timestamp":1782962700458,"version":"3.54.5"},"reference-count":28,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The prevalence of antithyroid drug (ATD)-related drug-induced liver injury (DILI) has been reported to vary among patients in several countries. The purpose of this study was to summarize the prevalence of liver injury induced by ATD and to determine the actual prevalence of severe liver injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The medical records of 18,558 patients who were newly diagnosed with Graves' disease between January 2005 and December 2016 were retrospectively reviewed. Severe DILI was defined as alanine aminotransferase (ALT) 8 times higher than the upper limit of normal (ULN) or total bilirubin (T-bil) 3 times higher than the ULN. The most severe DILI was defined as ALT higher than 20 times the ULN or T-bil higher than 10 times the ULN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 461 subjects (470 cases) were analyzed, and they consisted of 10 males and 451 females, with a median age of 37 years (range 10\u201382 years). Nine of 461 patients had severe DILI with both drugs. The total prevalence of severe DILI in this study was 2.5%, and the prevalence of DILI by drug was 1.4% with metimazole (MMI) (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009198) and 6.3% with propylthiouracil (PTU) (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u2009272) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The prevalence of the most severe ATD-related DILI was 0.22% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200940), and the prevalence for each drug was 0.08% with MMI (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200911) and 0.68% with PTU (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200929). The median time to DILI development was 30 days (range 7\u2013314 days), and all patients recovered from DILI, with no fatalities. The prevalence of MMI-related DILI was significantly age dependent (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Though there were no fatalities in this study, the prevalence of PTU-related severe DILI was significantly higher than that of MMI-related severe DILI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2019.0045","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T07:07:07Z","timestamp":1567753627000},"page":"1390-1398","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Analysis of Antithyroid Drug-Induced Severe Liver Injury in 18,558 Newly Diagnosed Patients with Graves\u2019 Disease in Japan"],"prefix":"10.1177","volume":"29","author":[{"given":"Nami","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeduk Yoshimura","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marino","family":"Hiruma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuha","family":"Morisaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Ohye","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo","family":"Kunii","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Iwaku","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiminori","family":"Sugino","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kochi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ito Hospital, Shibuya, 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