{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:53:19Z","timestamp":1784760799120,"version":"3.55.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The cribriform-morular variant (CMV) is a rare subtype of papillary thyroid carcinoma (PTC), and is often associated with familial adenomatous polyposis (FAP). This variant is generally indolent, but some aggressive cases have been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient Findings:<\/jats:title>\n                    <jats:p>\n                      We present the case of a 24-year-old woman who underwent total thyroidectomy with prophylactic central lymph node dissection and modified radical neck dissection for CMV-PTC. No distant metastases were identified preoperatively. However, multiple large lung metastases were detected three and half years after surgery. She also had FAP with a germline\n                      <jats:italic toggle=\"yes\">APC<\/jats:italic>\n                      gene mutation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary:<\/jats:title>\n                    <jats:p>She was started on lenvatinib because of the metastatic disease. One month after the initiation of lenvatinib (24\u2009mg), her lung metastases reduced significantly. She has continued lenvatinib for 24 months (present dose, 10\u2009mg). The lung metastases have not progressed during this period. Only a few small polyps were newly detected on endoscopy after lenvatinib administration. This number was considerably higher before therapy, when an average of 21\u201375 polyps were resected at each endoscopy session.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This is the first report of the use of lenvatinib for the treatment of distant metastases from CMV-PTC. In addition to the efficacy in treating metastatic lesions of this rare variant of PTC, lenvatinib shows promise in the management of associated FAP. This treatment strategy may be useful in the management of recurrent CMV-PTC and in those with FAP who refuse colectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2019.0121","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T07:27:31Z","timestamp":1563434851000},"page":"1511-1517","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Control of Lung Metastases and Colon Polyposis with Lenvatinib Therapy in a Patient with Cribriform-Morular Variant of Papillary Thyroid Carcinoma and an\n                    <i>APC<\/i>\n                    Gene Mutation: A Case Study"],"prefix":"10.1177","volume":"29","author":[{"given":"Yasuhiro","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Surgery, Kuma Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Ishikawa Gastroenterology Clinic, Osaka, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Kihara","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kuma Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Hirokawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kuma Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Kiyota","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Japan."},{"name":"Cancer Center, Kobe University Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kuma Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kuma Hospital, Kobe, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"e_1_3_2_2_2","first-page":"400","article-title":"Cribriform-morular variant of papillary carcinoma: a distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma?","volume":"12","author":"Cameselle-Teijeiro J","year":"1999","unstructured":"Cameselle-Teijeiro J, , Chan JK. 1999. Cribriform-morular variant of papillary carcinoma: a distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma?. Mod Pathol, 12:400\u2013411.","journal-title":"Mod Pathol"},{"key":"e_1_3_2_3_2","first-page":"81","volume-title":"WHO Classification of Tumours of Endocrine Organs","author":"Rosai JASJ","year":"2017","unstructured":"Rosai JASJ, , Asioli S, , Baloch ZW. 2017. Papillary thyroid carcinoma. In: Lloyd RVOR, , Kioppel G, , Rosai J (eds) WHO Classification of Tumours of Endocrine Organs. 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