{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:22:05Z","timestamp":1777875725084,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Elevated levels of antithyroperoxidase antibodies (TPOAbs) have been associated with progression of subclinical thyroid dysfunction, extrathyroidal diseases, and decrease in functional status. However, TPOAb as determinant of future thyroid dysfunction and other clinical outcomes has not been studied well for adults aged 85 years and over. This study aimed to assess associations of TPOAb levels with thyroid function, survival, physical function, disability in activities of daily living (ADL), cognitive function, and depressive symptoms in the oldest old.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Data from a population-based cohort study (Leiden 85-plus Study) of residents of Leiden, the Netherlands, aged 85 and older were used. Baseline serum TPOAb levels were available for 488 participants (82% of the total cohort). We considered levels \u226535 IU\/mL as elevated. Thyroid function (thyrotropin [TSH] and free thyroxine) was assessed at age 85 (baseline), 87, and 88 years. Survival, physical function, disability in ADL, cognitive function, and depressive symptoms were assessed from age 85 through 90 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At baseline, 64 of the 85-year old participants (13.1%) had elevated TPOAb levels. They were more often female, had higher TSH levels, and a higher prevalence of overt or subclinical hypothyroidism than participants with normal TPOAb levels. Over time, elevated TPOAb levels were independently associated with a lower mortality risk (hazard ratio 0.72, [95% confidence interval 0.53\u20130.99]), but were not associated with changes in thyroid function, nor with physical function, disability in ADL, cognitive function, or depressive symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In community-dwelling oldest old, elevated TPOAb levels are cross-sectionally associated with higher TSH levels. Over time, elevated TPOAb levels are associated with a survival benefit but are not associated with changes in thyroid function, functional status, or depressive symptoms in old age. The added clinical value of TPOAb tests in oldest old persons with thyroid dysfunction is limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2019.0129","type":"journal-article","created":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T04:03:12Z","timestamp":1565064192000},"page":"1201-1208","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Associations of Elevated Antithyroperoxidase Antibodies with Thyroid Function, Survival, Functioning, and Depressive Symptoms in the Oldest Old: The Leiden 85-plus Study"],"prefix":"10.1177","volume":"29","author":[{"given":"Robert S.","family":"Du Puy","sequence":"first","affiliation":[{"name":"Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalinde K.E.","family":"Poortvliet","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marieke","family":"Snel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy P.J.","family":"den Elzen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart E.P.B.","family":"Ballieux","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf M.","family":"Dekkers","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Endocrinology, Leiden University Medical Center, Leiden, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon P.","family":"Mooijaart","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacobijn","family":"Gussekloo","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands."},{"name":"Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,17]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1398.014"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16154-0"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP12280.GL"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01894.x"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03400020051029"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032061"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.7.8678"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3950"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/864907"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31819c0ecf"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346432"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0043"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)04430-9"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0008"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.2466\/pms.2001.93.2.323"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/002383099200500204"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1046\/j.1532-5415.2001.49181.x","article-title":"Disability in the oldest old: \u201ccan do\u201d or \u201cdo do\u201d?","volume":"49","author":"Bootsma-van der Wiel A","year":"2001","unstructured":"Bootsma-van der Wiel A, , Gussekloo J, , de Craen AJ, , van Exel E, , Knook DL, , Lagaay AM, , Westendorp RG. 2001. 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