{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:58:55Z","timestamp":1792177135816,"version":"4.4.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Cribriform\u2013morular variant of papillary thyroid carcinoma (CMV\u2013PTC) is a rare subtype of PTC, which occurrs predominantly in young women. This disease much more frequently presents in patients with familial adenomatous polyposis (FAP). FAP is an autosomal dominant inherited disease, which arises from germline mutations in the adenomatous polyposis coli (\n                      <jats:italic toggle=\"yes\">APC<\/jats:italic>\n                      ) gene. To clarify the distinctive clinical features of CMV\u2013PTC, a comparison study was performed between familial types and sporadic types.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Between 2007 and 2018, 15 CMV\u2013PTC patients underwent thyroidectomy in Samsung Medical Center. The clinical features of these patients were retrospectively reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All patients were women with a median age of 26 years (range 17\u201346 years). The median maximum diameter was 1.0\u2009cm (range 0.4\u20133.5\u2009cm). All tumors underwent immunostaining and showed nuclear and\/or cytoplasmic staining for \u03b2-catenin. On ultrasonography, most nodules had benign-looking features (well-defined, hypoechoic, and oval to round shapes without calcification), but a few nodules had capsular invasion and taller than wide shape. On preoperative fine-needle aspiration cytology, five patients (33%) were diagnosed as CMV\u2013PTC, nine (60%) as PTC, but one (7%) as follicular neoplasm or PTC\u2013follicular variant. Six patients (40%) had FAP, and four of them had total colectomy due to FAP. Five of them had a family history of FAP or colon cancer, or thyroid cancer. Germline mutations in the\n                      <jats:italic toggle=\"yes\">APC<\/jats:italic>\n                      gene were found in all six patients with CMV\u2013PTC associated with FAP, and five of them had\n                      <jats:italic toggle=\"yes\">de novo<\/jats:italic>\n                      mutations. All patients with FAP-associated CMV\u2013PTC had multiple tumors. All CMV\u2013PTC patients had excellent response to initial therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Because of the association between FAP or colon cancer with multifocal CMV\u2013PTC, we confirm that mutational analysis of the\n                      <jats:italic toggle=\"yes\">APC<\/jats:italic>\n                      gene and colonoscopy should be carried out in these patients when multiple thyroid tumors are found.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2019.0261","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T08:20:14Z","timestamp":1567153214000},"page":"1606-1614","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Multifocality in a Patient with Cribriform\u2013Morular Variant of Papillary Thyroid Carcinoma Is an Important Clue for the Diagnosis of Familial Adenomatous Polyposis"],"prefix":"10.1177","volume":"29","author":[{"given":"Jun","family":"Park","sequence":"first","affiliation":[{"name":"Division of Endocrinology &amp; Metabolism, Department of Medicine, Thyroid Centre, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Genetics, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunju","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Endocrinology &amp; Metabolism, Department of Medicine, Thyroid Centre, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Young","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Endocrinology &amp; Metabolism, Department of Medicine, Thyroid Centre, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hyuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology &amp; Metabolism, Department of Medicine, Thyroid Centre, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology &amp; Metabolism, Department of Medicine, Thyroid Centre, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Lyun","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hoon","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology &amp; Metabolism, Department of Medicine, Thyroid Centre, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"400","article-title":"Cribriform-morular variant of papillary carcinoma: a distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma?","volume":"12","author":"Cameselle-Teijeiro J","year":"1999","unstructured":"Cameselle-Teijeiro J, , Chan JK. 1999. Cribriform-morular variant of papillary carcinoma: a distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma?. Mod Pathol, 12:400\u2013411.","journal-title":"Mod Pathol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7475-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1309\/T9CC-JNMD-1WGP-YPAF"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201088"},{"key":"e_1_3_3_6_2","first-page":"95","article-title":"The genetic basis of familial adenomatous polyposis and its implications for clinical practice and risk management","volume":"8","author":"Leoz ML","year":"2015","unstructured":"Leoz ML, , Carballal S, , Moreira L, , Ocana T, , Balaguer F. 2015. The genetic basis of familial adenomatous polyposis and its implications for clinical practice and risk management. 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Thyroid carcinoma usually occurs in patients with familial adenomatous polyposis in the absence of biallelic inactivation of the adenomatous polyposis coli gene. 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