{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:08:37Z","timestamp":1790762917229,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      The thyroid hormones (THs) triiodothyronine (T3) and thyroxine (T4) are crucial regulators of brain development and function. Cell-specific transporter proteins facilitate TH uptake and efflux across the cell membrane, and insufficient TH transport causes hypothyroidism and mental retardation. Mutations in the TH transporters monocarboxylate transporter 8 (MCT8,\n                      <jats:italic toggle=\"yes\">SLC16A2<\/jats:italic>\n                      ) and the organic anion-transporting polypeptide 1C1 (OATP1C1,\n                      <jats:italic toggle=\"yes\">SLCO1C1<\/jats:italic>\n                      ) are associated with the psychomotor retardation Allan-Herndon-Dudley syndrome and juvenile neurodegeneration, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      To understand the mechanisms and test potential treatments for the recently discovered OATP1C1 deficiency, we established an\n                      <jats:italic toggle=\"yes\">oatp1c1<\/jats:italic>\n                      mutant (\n                      <jats:italic toggle=\"yes\">\n                        oatp1c1\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                      ) zebrafish.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">oatp1c1<\/jats:italic>\n                      is expressed in endothelial cells, neurons, and astrocytes in zebrafish. The activity of the hypothalamic\u2013pituitary\u2013thyroid axis and behavioral locomotor activity increased in\n                      <jats:italic toggle=\"yes\">\n                        oatp1c1\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                      larvae. Neuropathological analysis revealed structural alteration in radial glial cells and shorter neuronal axons in\n                      <jats:italic toggle=\"yes\">\n                        oatp1c1\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                      larvae and adults. Notably,\n                      <jats:italic toggle=\"yes\">\n                        oatp1c1\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">\n                        oatp1c1\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                      X\n                      <jats:italic toggle=\"yes\">\n                        mct8\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                      adults exhibit an enlarged thyroid gland (goiter). Pharmacological assays showed that TH analogs, but not THs, can reduce the size and improve the color of the thyroid gland in adult mutant zebrafish.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      These results establish a vertebrate model for OATP1C1 deficiency that demonstrates endocrinological, neurological, and behavioral alterations mimicking findings observed in an OATP1C1-deficient patient. Further, the curative effect of TH analogs in the\n                      <jats:italic toggle=\"yes\">\n                        oatp1c1\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                      zebrafish model may provide a lead toward a treatment modality in human patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2019.0320","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T07:49:59Z","timestamp":1575445799000},"page":"161-174","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Neural Alterations and Hyperactivity of the Hypothalamic\u2013Pituitary\u2013Thyroid Axis in Oatp1c1 Deficiency"],"prefix":"10.1177","volume":"30","author":[{"given":"Inbal","family":"Admati","sequence":"first","affiliation":[{"name":"The Faculty of Life Sciences and The Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talya","family":"Wasserman-Bartov","sequence":"additional","affiliation":[{"name":"The Faculty of Life Sciences and The Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Tovin","sequence":"additional","affiliation":[{"name":"The Faculty of Life Sciences and The Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rotem","family":"Rozenblat","sequence":"additional","affiliation":[{"name":"The Faculty of Life Sciences and The Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einat","family":"Blitz","sequence":"additional","affiliation":[{"name":"The Faculty of Life Sciences and The Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zada","sequence":"additional","affiliation":[{"name":"The Faculty of Life Sciences and The Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tali","family":"Lerer-Goldshtein","sequence":"additional","affiliation":[{"name":"The Faculty of Life Sciences and The Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"The Faculty of Life Sciences and The Multidisciplinary Brain Research Center, Bar-Ilan University, Ramat-Gan, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1097"},{"key":"e_1_3_4_3_2","volume-title":"Endotext","author":"Segni M","year":"2000","unstructured":"Segni M. 2000. 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