{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:59:57Z","timestamp":1783486797200,"version":"3.55.0"},"reference-count":47,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      The impact of thyroid disorders on\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      outcomes of assisted reproductive technology (ART) remains controversial. Therefore, the aim of our study was to investigate whether thyroid peroxidase antibodies (TPO-Abs)\/thyroid autoimmunity (TAI) or thyroid function (serum thyrotropin [TSH])\/subclinical hypothyroidism are associated with an altered number of oocyte retrieval (NOR), fertilization rate (FR), and embryo quality (EQ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Cross-sectional study in 279 women in a single center, comprising 297 cycles and 1168 embryos.\n                      <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                      data (NOR, FR, and EQ) were documented in two groups; one according to thyroid function in women without TAI (TSH \u22642.5 and &gt;2.5 mIU\/L) and one according to the presence\/absence of TAI (determined by TPO-Abs). EQ was evaluated according to international criteria and classified as excellent\/good and poor. Women treated with levothyroxine (LT4) were excluded. Furthermore, the impact of thyroid parameters on outcomes, normal NOR (&gt;6 or 8) and high FR (&gt;60%), was verified in a multivariable logistic regression model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In women without TAI, 27% had TSH levels &gt;2.5 mIU\/L, the prevalence of TAI was 8%, and overall, 6% of women had TSH levels &gt;4.2 mIU\/L. NOR, FR, and EQ were comparable between study groups. In the regression analysis, women aged \u226530 years and receiving a high ovarian stimulation dosage (&gt;2300 IU\/cycle) had lower rates of normal NOR (odds ratio [OR] 0.18 [95% confidence interval, CI 0.04\u20130.72];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.016 and OR 0.17 [CI 0.06\u20130.48];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Our results do not suggest an impact of thyroid antibodies\/autoimmunity and (dys)function on ART\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      outcomes.\n                    <\/jats:p>\n                  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Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Rozenberg","sequence":"additional","affiliation":[{"name":"Gynecology, Obstetrics, and Reproductive Medicine Unit and Universit\u00e9 Libre de Bruxelles (ULB), Brussels, 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