{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:24:48Z","timestamp":1783488288084,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitamin D deficiency has been proposed to have a role in the development and course of Graves' disease (GD). Muscle weakness and quality of life (QoL) impairments are shared features of GD and vitamin D deficiency. We aimed at investigating whether vitamin D supplementation would improve restoration of muscle performance and thyroid-related QoL in GD and at describing the effect of anti-thyroid medication (ATD) on these outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      In a double-blinded clinical trial, hyperthyroid patients with a first-time diagnosis of GD were randomized to vitamin D 70\u2009\u03bcg (2800 IU)\/day or matching placebo as add-on to standard ATD. At baseline and after 3 and 9 months of intervention, we assessed isometric muscle strength, muscle function tests, postural stability, body composition, and QoL-impairment by using the ThyPRO questionnaire. Linear mixed modeling was used to analyze between-group differences. (The DAGMAR study\n                      <jats:uri xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:uri>\n                      ID NCT02384668).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Nine months of vitamin D supplementation caused an attenuation of muscle strength increment in all muscle measures investigated, significant at knee extension 60\u00b0 where the increase was 24% lower (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.04) in the vitamin D group compared with placebo. Compared with placebo, vitamin D supplementation tended to reduce gain of lean body mass (\u221224%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.08). Vitamin D supplementation significantly impeded alleviation of Composite QoL and the same trend was observed for the Overall QoL-Impact and Impaired Daily Life scales. In response to ATD, all measures improved significantly. The increase in muscle strength ranged from 25% to 40% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      <jats:sub>all<\/jats:sub>\n                      &lt; 0.001), and increment of lean body mass was 10% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Large changes were observed in all QoL scales.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Nine months of vitamin D supplementation caused unfavorable effects on restoration of muscle performance. In contrast, ATD treatment was associated with marked improvement in all measures of muscle performance and thyroid-related QoL. In patients with newly diagnosed GD, high-dose vitamin D supplementation should not be recommended to improve muscle function, but ATD is of major importance to alleviate muscle impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2019.0634","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T15:49:20Z","timestamp":1578412160000},"page":"661-671","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects of Supplemental Vitamin D on Muscle Performance and Quality of Life in Graves' Disease: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"30","author":[{"given":"Diana","family":"Grove-Laugesen","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Karkov","family":"Cramon","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Malmstroem","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Ebbehoj","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torquil","family":"Watt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gentofte and Herlev Hospital, Herlev, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klavs W\u00fcrgler","family":"Hansen","sequence":"additional","affiliation":[{"name":"Medical Department, Regional Hospital Silkeborg, Silkeborg, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Rejnmark","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510030"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)90536-8"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0318"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0044"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0315"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.3.752"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030604"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1525"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu7042485"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu7053813"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001639"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-01997-8"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000074446.02192.14"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-013-0462-1"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00700.x"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0209"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0224"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1742"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03733.x"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2014.07.022"},{"key":"e_1_3_4_24_2","first-page":"859","article-title":"Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis","volume":"22","author":"Stockton KA","year":"2011","unstructured":"Stockton KA, , Mengersen K, , Paratz JD, , Kandiah D, , Bennell KL. 2011. 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