{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:15:33Z","timestamp":1791587733492,"version":"4.3.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>No direct prospective studies comparing laser ablation (LA) and radiofrequency ablation (RFA) for debulking benign non-functioning thyroid nodules (BNTNs) exist. We aimed at comparing the efficacy and safety of both techniques in patients with solid or predominantly solid BNTN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This six-month, single-use, randomized, open-label, parallel trial compared the following primary endpoints between the RFA and LA groups six months after treatment: (i) nodule volume reduction expressed as a percentage of nodule volume at baseline; (ii) proportion of nodules with more than 50% reduction (successful rate). We enrolled subjects with a solitary BNTN or dominant nodule characterized by pressure symptoms\/cosmetic problems or patients without symptoms who experienced a volume increase &gt;20% in one year. Nodules underwent core needle biopsy for diagnosis. Patients were randomly assigned (1:1) to receive LA or RFA. Safety was assessed in all randomly assigned participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Sixty patients were randomly assigned to receive either RFA or LA (1:1) between January 2016 and November 2018. Both groups were similar in basal nodule volume, thyroid function, histology, symptoms\/cosmetic score, and procedure time. At six months, the nodule volume reduction was 64.3% (95% confidence interval, CI 57.5\u201371.2) in the RFA group and 53.2% ([CI 47.2\u201395.2];\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02) in the LA group. This effect was also confirmed in the linear regression model adjusted for age, baseline volume, and proportion of cellular component (LA vs. RFA percent change Delta\u2009=\u2009\u221212.8,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02). No significant difference was observed in success rate six months after treatment (RFA vs. LA: 86.7% vs. 66.7%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.13) or in thyrotropin level between the groups. Although improved, no significant difference was observed between RFA and LA for compressive symptoms (RFA: 2.13 vs. 3.9,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090\u2009\u00b7\u2009001; LA: 2.4 vs. 3.87,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and cosmetic score (RFA: 1.65 vs. 2.2,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001; LA: 1.85 vs. 2.2,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The adverse event rates (local pain, dysphonia, thyrotoxicosis, fever, hematoma) were 37% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200911) and 43% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200913) for RFA and LA, respectively, with no requirement for hospitalization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although the success rate was similar in the RFA and LA groups, RFA achieved a significantly larger nodule volume reduction at six months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2019.0660","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T06:09:34Z","timestamp":1581660574000},"page":"847-856","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":71,"title":["Laser Ablation Versus Radiofrequency Ablation for Benign Non-Functioning Thyroid Nodules: Six-Month Results of a Randomized, Parallel, Open-Label, Trial (LARA Trial)"],"prefix":"10.1177","volume":"30","author":[{"given":"Roberto","family":"Cesareo","sequence":"first","affiliation":[{"name":"Unit of Metabolic Diseases, \u201cS.M. Goretti\u201d Hospital, Latina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Maurizio","family":"Pacella","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, Regina Apostolorum Hospital, Albano Laziale, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Pasqualini","sequence":"additional","affiliation":[{"name":"Department of Radiology and \u201cS.M. Goretti\u201d Hospital, Latina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Campagna","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u201cS.M. Goretti\u201d Hospital, Latina, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Iozzino","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, Regina Apostolorum Hospital, Albano Laziale, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Sapienza University of Rome, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Lauria Pantano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Campus Bio-Medico, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cianni","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, S. Camillo Hospital, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Pedone","sequence":"additional","affiliation":[{"name":"Geriatric Unit, Campus Bio-Medico University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pozzilli","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Taffon","sequence":"additional","affiliation":[{"name":"Pathology Unit, University Hospital Campus Bio-Medico, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Crescenzi","sequence":"additional","affiliation":[{"name":"Pathology Unit, University Hospital Campus Bio-Medico, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Manfrini","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Palermo","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes, Campus Bio-Medico University, Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP161208.GL"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.08.008"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0309"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13422"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.14366\/usg.18034"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2019.1575482"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1826"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871530319666190206123156"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02808"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2186"},{"key":"e_1_3_5_12_2","first-page":"911","article-title":"A comparison of laser with radiofrequency ablation for the treatment of benign thyroid nodules: a propensity score matching analysis","volume":"33","author":"Pacella CM","year":"2017","unstructured":"Pacella CM, , Mauri G, , Cesareo R, , Paqualini V, , Cianni R, , De Feo P, , Gambelunghe G, , Raggiunti B, , Tina D, , Deandrea M, , Limone PP, , Mormile A, , Giusti M, , Oddo S, , Achille G, , Di Stasio E, , Misischi I, , Papini E. 2017. A comparison of laser with radiofrequency ablation for the treatment of benign thyroid nodules: a propensity score matching analysis. Int J Hyperthermia, 33:911\u2013919.","journal-title":"Int J Hyperthermia"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0685"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4077"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2016.1244707"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-019-09487-y"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02019-3"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.3372"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2016.02.15"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-008-0880-6"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jus.2012.09.001"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.4.632"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000094584.83406.3e"},{"key":"e_1_3_5_24_2","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988","unstructured":"Cohen J. 1988. Statistical Power Analysis for the Behavioral Sciences, 2nd ed. L. Erlbaum, Hillsdale, NJ.","edition":"2"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.0204"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/1553350612459276"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2671-3"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1829-4"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2019.1627432"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1530\/EC-19-0236"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2017.32.4.407"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.2478\/joeb-2018-0019"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10081634"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.0082"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2463070390"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.1.167"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/thy.2019.0660","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2019.0660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2019.0660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:06:44Z","timestamp":1777586804000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/thy.2019.0660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1089\/thy.2019.0660"],"URL":"https:\/\/doi.org\/10.1089\/thy.2019.0660","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]}}}