{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:22:53Z","timestamp":1777875773046,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Thyroid\u00ae"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The surgical management of nodular thyroid disease has been influenced by the advent of molecular diagnostics and recent guidelines recommending a more conservative approach to low-risk thyroid tumors. The purpose of this study was to assess practice changes arising from the early adoption of current literature within a single high-volume center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cohort study of all patients evaluated or surgically treated for known or suspected thyroid cancer at a single institution was performed (2010\u20132018). We analyzed the yield of diagnostic thyroidectomy for indeterminate (Bethesda III and IV) nodules, the choice of initial operation for likely malignant (Bethesda V and VI) nodules, and the rate of completion thyroidectomy. The Cochran\u2013Armitage test was used to assess the significance of any observed trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 2497 patients who underwent initial thyroidectomy from 2010 to 2018, 1791 patients had a tissue diagnosis of suspected or known thyroid cancer by cytopathology (Bethesda III\u2013VI) or surgical pathology (differentiated thyroid cancer). In patients with likely malignant nodules but no clinical evidence of invasive or metastatic disease, the proportion managed with total thyroidectomy plus prophylactic neck dissection fell from 50% to 10% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.007). The proportion with likely malignant nodules managed definitively with thyroid lobectomy rose from 2% to 19% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The rate of completion thyroidectomy for thyroid cancer found in the initial lobectomy specimen declined from 73% to 26% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Among all patients with cytologically indeterminate nodules (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091036), we observed a decrease in the rate of diagnostic thyroidectomy from 67% to 35% over the study period (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.015).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The early adoption of new diagnostic technology and management guidelines has manifested in a less aggressive surgical approach to known or suspected thyroid cancer. Long-term follow-up will be required to assess oncologic and patient-centered outcomes arising from this modern strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/thy.2019.0783","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T07:18:48Z","timestamp":1591687128000},"page":"1639-1645","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Trends in the Surgical Management of Known or Suspected Differentiated Thyroid Cancer at a Single Institution, 2010\u20132018"],"prefix":"10.1177","volume":"30","author":[{"given":"Catherine Y.","family":"Zhu","sequence":"first","affiliation":[{"name":"Section of Endocrine Surgery, Department of Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Sha","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Department of Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Hong","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of California Los Angeles Fielding School of Public Health, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Eun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren E.","family":"Orr","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Department of Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin W.","family":"Wong","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Department of Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masha J.","family":"Livhits","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Department of Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyu","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Department of Surgery, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"National Cancer Institute Surveillance Epidemiology and End Results Program (SEER) Cancer Stat Facts: Thyroid Cancer. Available at https:\/\/seer.cancer.gov\/statfacts\/html\/thyro.html (accessed February2 2020)."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2719"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24416"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20830"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23116"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000925"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21504"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0386"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21439"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21624"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4616"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02754"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2018-0395"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2018.0726"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00255"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001688"}],"container-title":["Thyroid\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/thy.2019.0783","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2019.0783","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/thy.2019.0783","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:06:56Z","timestamp":1777586816000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/thy.2019.0783"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1089\/thy.2019.0783"],"URL":"https:\/\/doi.org\/10.1089\/thy.2019.0783","relation":{},"ISSN":["1050-7256","1557-9077"],"issn-type":[{"value":"1050-7256","type":"print"},{"value":"1557-9077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}